Polyamines are molecules with multiple amino groups that are essential for cellular function.
The major polyamines are putrescine, spermidine, spermine, and cadaverine. Polyamines …

Alzheimer's disease (AD) is a devastating neurodegenerative disorder characterized by
progressive cognitive decline and a significant societal burden. Despite extensive research …

Metformin is the first-line treatment for type 2 diabetes, yet its mechanism of action is not fully
understood. Recent studies suggest metformin's interactions with gut microbiota are …

In this study, we synthesized a novel compound, agmatine-cholesterol conjugate (AG-Chol),
to enhance the anti-tumor activity of drug-loaded liposomes. We replaced cholesterol with …

Objective: To assess the nephroprotective potential of agmatine in a rat model of
streptozotocin-induced diabetic nephropathy. Methods: A single dose of streptozotocin (40 …

Agmatine (AGM), a naturally occurring polyamine derived from L-arginine, has shown
significant potential for neuroprotection in Parkinson's Disease (PD) due to its multifaceted …

Colorectal cancer (CRC), a malignant tumor worldwide, is associated with gut microbiota.
The influence of gut microbe-derived metabolites on CRC has attracted a lot of attention …

Arginine‐ornithine metabolism plays a crucial role in bacterial homeostasis, as evidenced
by numerous studies. However, the utilization of arginine and the downstream products of its …

Abstract Agmatine, 1-Amino-4-guanidinobutane, is a ubiquitous naturally occurring
molecule present in low amounts in a wide variety of foodstuff. Clinical trials have …

Polyamine (PA) spermidine (SPD) plays a crucial role in aging. Since SPD accumulates in
glial cells, particularly in Müller retinal cells (MCs), the expression of the SPD-synthesizing …