Immunomodulation and immunopharmacology in heart failure
G Markousis-Mavrogenis, L Baumhove… - Nature Reviews …, 2024 - nature.com
The immune system is intimately involved in the pathophysiology of heart failure. However, it
is currently underused as a therapeutic target in the clinical setting. Moreover, the …
is currently underused as a therapeutic target in the clinical setting. Moreover, the …
When cardiovascular medicines should be discontinued
KA Krychtiuk, BJ Gersh, JB Washam… - European Heart …, 2024 - academic.oup.com
An integral component of the practice of medicine is focused on the initiation of medications,
based on clinical practice guidelines and underlying trial evidence, which usually test the …
based on clinical practice guidelines and underlying trial evidence, which usually test the …
Comparative Outcomes of Empagliflozin to Dapagliflozin in Patients With Heart Failure
KL Modzelewski, A Pipilas, NA Bosch - JAMA Network Open, 2024 - jamanetwork.com
Importance Sodium-glucose cotransporter-2 (SGLT2) inhibitors have been shown to have
benefits when used in patients with heart failure. The comparative outcomes of SGLT2 …
benefits when used in patients with heart failure. The comparative outcomes of SGLT2 …
Underrepresentation of women in reduced ejection heart failure clinical trials with improved mortality or hospitalization
Background There are established sex-specific differences in heart failure with reduced
ejection fraction (HFrEF) outcomes. Randomized clinical trials (RCTs) based on …
ejection fraction (HFrEF) outcomes. Randomized clinical trials (RCTs) based on …
Contemporary pharmacological treatment and management of heart failure
B Bozkurt - Nature Reviews Cardiology, 2024 - nature.com
The prevention and treatment strategies for heart failure (HF) have evolved in the past two
decades. The stages of HF have been redefined, with recognition of the pre-HF state, which …
decades. The stages of HF have been redefined, with recognition of the pre-HF state, which …
Out-of-pocket prescription drug costs for adults with cardiovascular risk factors under Amazon's direct-to-consumer pharmacy service
Background US adults often overpay for generic prescription medications, which can lead to
medication nonadherence that negatively impacts cardiovascular outcomes. As a result …
medication nonadherence that negatively impacts cardiovascular outcomes. As a result …
Internalized β2-Adrenergic Receptors Oppose PLC-Dependent Hypertrophic Signaling
BACKGROUND: Chronically elevated neurohumoral drive, and particularly elevated
adrenergic tone leading to β-adrenergic receptor (β-AR) overstimulation in cardiac …
adrenergic tone leading to β-adrenergic receptor (β-AR) overstimulation in cardiac …
[HTML][HTML] Carvedilol Activates a Myofilament Signaling Circuitry to Restore Cardiac Contractility in Heart Failure
Y Wang, M Zhao, X Liu, B Xu, GR Reddy… - JACC: Basic to …, 2024 - Elsevier
Phosphorylation of myofilament proteins critically regulates beat-to-beat cardiac contraction
and is typically altered in heart failure (HF). β-Adrenergic activation induces phosphorylation …
and is typically altered in heart failure (HF). β-Adrenergic activation induces phosphorylation …
Analysis of the anti-PCV2 mechanism of Lactobacillus acidophilus based on non-target metabolomics and high-throughput molecular docking
Z Cao, X Ling, A Haseeb, P Sun, H Zhang… - Frontiers in …, 2024 - frontiersin.org
Our previous studies have revealed that L. acidophilus possesses inhibitory effects on PCV2
proliferation in vivo, although the underlying mechanisms remain elusive. Probiotics like L …
proliferation in vivo, although the underlying mechanisms remain elusive. Probiotics like L …
[HTML][HTML] The ric-8b protein (resistance to inhibitors of cholinesterase 8b) is key to preserving contractile function in the adult heart
E Tsisanova, M Nobles, S Sebastian, KE Ng… - Journal of Biological …, 2024 - Elsevier
Resistance to inhibitors of cholinesterases (ric-8 proteins) are involved in modulating G-
protein function but little is known of their potential physiological importance in the heart. In …
protein function but little is known of their potential physiological importance in the heart. In …