Synergistic anticancer effect by targeting CDK2 and EGFR–ERK signaling
J Wu, Y Chen, R Li, Y Guan, M Chen, H Yin… - Journal of Cell …, 2024 - rupress.org
The EGFR-RAS-ERK pathway is one of the most important signaling cascades in cell
survival, growth, and proliferation. Aberrant activation of this pathway is a common …
survival, growth, and proliferation. Aberrant activation of this pathway is a common …
Key roles of Ubiquitination in Regulating Critical Regulators of cancer stem cell functionality
Q Guo, H Qin, Z Chen, W Zhang, L Zheng, T Qin - Genes & Diseases, 2024 - Elsevier
The ubiquitin (Ub) system, a ubiquitous presence across eukaryotes, plays a crucial role in
the precise orchestration of diverse cellular protein processes. From steering cellular …
the precise orchestration of diverse cellular protein processes. From steering cellular …
MAP3K1 regulates female reproductive tract development
E Kimura, M Mongan, B Xiao… - Disease Models & …, 2024 - journals.biologists.com
ABSTRACT Mitogen-activated protein 3 kinase 1 (MAP3K1) has a plethora of cell type-
specific functions not yet fully understood. Herein, we describe a role for MAP3K1 in female …
specific functions not yet fully understood. Herein, we describe a role for MAP3K1 in female …
Lactate accelerates cancer progression through the ERK-GCN5 lactylation-phosphorylation feedback cascade
B Huang, Y Chen, G Cui, G Mer, C Zhong… - Available at SSRN …, 2024 - papers.ssrn.com
Released lactate promotes cancer progression, but the mechanisms remain unclear. Here,
we found lactate activated MAPK pathway through ERK-lactylation to promote cancer …
we found lactate activated MAPK pathway through ERK-lactylation to promote cancer …
Enhancement of ubiquitination-dependent mitophagy by unconventionally-acting PROTACs
L Wen - 2024 - researchsquare.com
Enhancing mitophagy, a naturally-occurring cellular process for elimination of damaged
mitochondria, holds great promise for the intervention of many human diseases. Proteolysis …
mitochondria, holds great promise for the intervention of many human diseases. Proteolysis …
Targeted Degradation of Intracellular Proteins using Ubiquitin Variant Induced Proximity
B Aminu - 2024 - atrium.lib.uoguelph.ca
Eukaryotic cells rely on proteasomal degradation mechanisms to maintain protein
homeostasis, quantity, and quality, essential for regulating various biological processes. A …
homeostasis, quantity, and quality, essential for regulating various biological processes. A …