The transcription factor p73, a member of the p53 tumor-suppressor family, regulates cell
death and also supports tumorigenesis, although the mechanistic basis for the dichotomous …

The p63 protein has pleiotropic functions and, in the liver, participates in the progression of
nonalcoholic fatty liver disease (NAFLD). However, its functions in hepatic stellate cells …

Objective p63 is a transcription factor involved in multiple biological functions. In the liver,
the TAp63 isoform induces lipid accumulation in hepatocytes. However, the role of liver …

Glioblastoma multiforme (GBM) is a fast-growing and aggressive brain tumour, which
remains largely resistant to treatment; the prognosis for patients is poor, with a median …

Aim: Acute respiratory distress syndrome (ARDS)/acute lung injury (ALI) is a severe clinical
respiratory-failure disease mainly characterized by acute damage to the alveolar epithelium …

The effect of mutations in the P53 family of transcription factors on their biological functions,
including partial or complete loss of transcriptional activity, has been confirmed several …

Abstract p53 is one of the most popular research objects among scientists. Over the past 40
years since its discovery, more than 100 thousand scientific works have been written and …

The p53 gene family, a well-known group of genes, is the primary propagator of tumor-
suppressing mechanisms in multicellular organisms. Although they are currently critical drug …

Hepatocellular carcinoma (HCC) represents a major and increasing health problem,
however, the therapy options for advanced stage HCC are very limited. Recent studies …