Innate immunity in protection and pathogenesis during coronavirus infections and COVID-19
RKS Malireddi, BR Sharma… - Annual Review of …, 2024 - annualreviews.org
The COVID-19 pandemic was caused by the recently emerged β-coronavirus SARS-CoV-2.
SARS-CoV-2 has had a catastrophic impact, resulting in nearly 7 million fatalities worldwide …
SARS-CoV-2 has had a catastrophic impact, resulting in nearly 7 million fatalities worldwide …
qSOFA combined with suPAR for early risk detection and guidance of antibiotic treatment in the emergency department: a randomized controlled trial
ME Adami, A Kotsaki, N Antonakos, E Giannitsioti… - Critical Care, 2024 - Springer
Background Sepsis guidelines suggest immediate start of resuscitation for patients with
quick Sequential Organ Failure Assessment (qSOFA) 2 or 3. However, the interpretation of …
quick Sequential Organ Failure Assessment (qSOFA) 2 or 3. However, the interpretation of …
Towards improved point-of-care (POC) testing for patients with suspected sepsis: POC tests for host biomarkers and possible microbial pathogens
ME Adami, EJ Giamarellos-Bourboulis… - Expert Review of …, 2024 - Taylor & Francis
Introduction Sepsis is a heterogeneous syndrome often misdiagnosed. Point-of-care (POC)
diagnostic tests are commonly used to guide decision and include host biomarkers and …
diagnostic tests are commonly used to guide decision and include host biomarkers and …
SuPAR, biomarkers of inflammation, and severe outcomes in patients hospitalized for COVID‐19: The International Study of Inflammation in COVID‐19
A Vasbinder, K Padalia, I Pizzo… - Journal of Medical …, 2024 - Wiley Online Library
Abstract Severe coronavirus disease 2019 (COVID‐19) is a hyperinflammatory syndrome.
The biomarkers of inflammation best suited to triage patients with COVID‐19 are unknown …
The biomarkers of inflammation best suited to triage patients with COVID‐19 are unknown …
Using Machine Learning to Determine a Suitable Patient Population for Anakinra for the Treatment of COVID‐19 Under the Emergency Use Authorization
A randomized, double‐blind, placebo‐controlled study (SAVEMORE trial) provided data to
support an Emergency Use Authorization (EUA) of anakinra in hospitalized adults with …
support an Emergency Use Authorization (EUA) of anakinra in hospitalized adults with …
Calprotectin serum levels on admission and during follow-up predict severity and outcome of patients with COVID-19: A prospective study
NK Gatselis, A Lyberopoulou, V Lygoura… - European Journal of …, 2024 - Elsevier
Abstract Background & Aims Calprotectin reflects neutrophil activation and is increased in
various inflammatory conditions including severe COVID-19. However, serial serum …
various inflammatory conditions including severe COVID-19. However, serial serum …
Longitudinal soluble marker profiles reveal strong association between cytokine storms resulting from macrophage activation and disease severity in COVID-19 …
KE van Meijgaarden, S van Veen, R Tsonaka… - Scientific Reports, 2024 - nature.com
SARS-CoV2 infection results in a range of disease severities, but the underlying differential
pathogenesis is still not completely understood. At presentation it remains difficult to …
pathogenesis is still not completely understood. At presentation it remains difficult to …
Association study between killer immunoglobulin-like receptor polymorphisms and susceptibility to COVID-19 disease: a systematic review and meta-analysis
SH Teshnizi, S Mirzazadeh, N Mashhadi, S Meri… - Immunologic …, 2024 - Springer
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a known virus that leads
to a respiratory disease called coronavirus disease 19 (COVID-19). Natural killer (NK) cells …
to a respiratory disease called coronavirus disease 19 (COVID-19). Natural killer (NK) cells …
[HTML][HTML] Clinical Phenotyping for Prognosis and Immunotherapy Guidance in Bacterial Sepsis and COVID-19
E Karakike, S Metallidis, G Poulakou… - Critical care …, 2024 - journals.lww.com
OBJECTIVES: It is suggested that sepsis may be classified into four clinical phenotypes,
using an algorithm employing 29 admission parameters. We applied a simplified …
using an algorithm employing 29 admission parameters. We applied a simplified …
The Soluble Urokinase Plasminogen Activator Receptor as a Severity Biomarker in Children With Acute COVID-19 or Multisystem Inflammatory Syndrome
M Louka, EB Tatsi, S Vassiliu, G Theoharis… - The Pediatric …, 2024 - journals.lww.com
Background: Elevated soluble urokinase plasminogen activator receptor (suPAR) has been
associated with a poor prognosis in serious infections. The aim of this study was to evaluate …
associated with a poor prognosis in serious infections. The aim of this study was to evaluate …