With the hope that disease-modifying treatments could target the molecular basis of
Parkinson's disease, even before the onset of symptoms, we propose a biologically based …

Abstract α-Synuclein and tau are abundant multifunctional brain proteins that are mainly
expressed in the presynaptic and axonal compartments of neurons, respectively. Previous …

α‐Synuclein (αS) is a key molecule in the pathomechanism of Parkinson's disease. Most
studies on αS to date have focused on its function in the neuronal cytosol, but its action in …

Abstract 5q-associated spinal muscular atrophy (SMA) is a motoneuron disease caused by
mutations in the survival motor neuron 1 (SMN1) gene. Adaptive immunity may contribute to …

Abberent protein-protein interactions potentiate many diseases and one example is the
toxic, self-assembly of α-Synuclein in the dopaminergic neurons of patients with Parkinson's …

The Parkinson's‐associated protein α‐synuclein (α‐syn) can undergo liquid–liquid phase
separation (LLPS), which typically leads to the formation of amyloid fibrils. The coincidence …

Although evidence indicates that the abnormal accumulation of α‐synuclein (α‐syn) in
dopamine neurons of the substantia nigra is the main pathological feature of Parkinson's …

Parkinson's disease (PD) is a neurodegenerative disease characterized by progressive
motor symptoms and alpha-synuclein (αsyn) aggregation in the nervous system. For unclear …

Background: Pre-clinical studies suggest that c-Abl activation may play an important role in
the etiology of Parkinson's disease, making c-Abl an important target to evaluate for potential …

Amyloid fibrils are characteristic of many neurodegenerative diseases, including Alzheimer's
and Parkinson's diseases. While different diseases may have fibrils formed of the same …