Paracetamol (acetaminophen) was marketed in the 1950s as a nonprescription
analgesic/antipyretic without any preclinical toxicity studies. It became used increasingly for …

Background As a canonical iron-dependent form of regulated cell death (RCD), ferroptosis
plays a crucial role in chemical-induced liver injuries. Previous studies have demonstrated …

Acetaminophen (APAP) overdose is steadily becoming the chief reason for drug-induced
acute liver failure, yet limited treatment is currently clinically available. Considering that the …

Larsucosterol, a potent endogenous epigenetic regulator, has been reported to play a
significant role in lipid metabolism, inflammatory responses, and cell survival. The …

Limonin is a natural tetracyclic triterpenoid compound in citrus seeds that presents
hepatoprotective effects but is often discarded as agricultural waste because of its low …

Abstract Aims/Introduction Mitochondrial damage caused by oxidative stress is a main driver
of pancreatic β‐cell dysfunction in the pathogenesis of type 2 diabetes mellitus. Prohibitin2 …

Acetaminophen (APAP), a widely used pain and fever reliever, is a major contributor to drug-
induced liver injury, as its toxic metabolites such as NAPQI induce oxidative stress and …

Abstract Ethnopharmacological relevance Paeonia lactiflora Pall.(PLP), a traditional
Chinese medicine, is recognized for its antioxidative and anti-apoptotic properties. Despite …

Abstract Ethnopharmacological relevance Abrus cantoniensis Hance (AC), an abrus
cantoniensis herb, is a Chinese medicinal herb used for the treatment of hepatitis. Total …

APAP (Acetaminophen)-induced hepatic injury is a major public health threat that requires
continuous searching for new effective therapeutics. KSG (Kaempferol-3-sophoroside-7 …