Microglia regulation of central nervous system myelin health and regeneration

SA Kent, VE Miron - Nature Reviews Immunology, 2024 - nature.com
Microglia are resident macrophages of the central nervous system that have key functions in
its development, homeostasis and response to damage and infection. Although microglia …

The role of kinases in peripheral nerve regeneration: mechanisms and implications

X Zhang, X Duan, X Liu - Frontiers in Neurology, 2024 - frontiersin.org
Peripheral nerve injury disease is a prevalent traumatic condition in current medical
practice. Despite the present treatment approaches, encompassing surgical sutures …

Remyelinating effect driven by transferrin‐loaded extracellular vesicles

V Mattera, F Occhiuzzi, J Correale, JM Pasquini - Glia, 2024 - Wiley Online Library
Extracellular vesicles (EVs) are involved in diverse cellular functions, playing a significant
role in cell‐to‐cell communication in both physiological conditions and pathological …

Evidence for decreased copper associated with demyelination in the corpus callosum of cuprizone-treated mice

JBW Hilton, K Kysenius, JR Liddell, SW Mercer… - Metallomics, 2024 - academic.oup.com
Demyelination within the central nervous system (CNS) is a significant feature of debilitating
neurological diseases such as multiple sclerosis and administering the copper-selective …

[HTML][HTML] Erinacine S, a small active component derived from Hericium erinaceus, protects oligodendrocytes and alleviates mood abnormalities in cuprizone-exposed …

JT Fu, CJ Yang, LY Lee, WP Chen, YW Chen… - Biomedicine & …, 2024 - Elsevier
Hericium erinaceus mycelium extract (HEM), containing erinacine A (HeA) and erinacine S
(HeS), has shown promise in promoting the differentiation of oligodendrocyte precursor cells …

Identification of crucial inflammaging related risk factors in multiple sclerosis

M Xu, H Wang, S Ren, B Wang, W Yang… - Frontiers in Molecular …, 2024 - frontiersin.org
Background Multiple sclerosis (MS) is an immune-mediated disease characterized by
inflammatory demyelinating lesions in the central nervous system. Studies have shown that …

The preferential effect of Clemastine on F3/Contactin-1/Notch-1 compared to Jagged-1/Notch-1 justifies its remyelinating effect in an experimental model of multiple …

SM Ibrahim, AS Kamel, KA Ahmed… - International …, 2024 - Elsevier
Clemastine (CLM) is repurposed to enhance remyelination in multiple sclerosis (MS)
patients. CLM blocks histamine and muscarinic receptors as negative regulators to …

Neuroprotective effects of rutin against cuprizone-induced multiple sclerosis in mice

MA Nicola, AH Attaai, MH Abdel-Raheem… - …, 2024 - Springer
Multiple sclerosis (MS) is a chronic inflammatory neurodegenerative disease of the central
nervous system that injures the myelin sheath, provoking progressive axonal degeneration …

The effects of venlafaxine on depressive-like behaviors and gut microbiome in cuprizone-treated mice

C Du, T Zhang, C Feng, Q Sun, ZG Chen… - Frontiers in …, 2024 - frontiersin.org
Background Cuprizone (CPZ)-treated mice show significant demyelination, altered gut
microbiome, and depressive-like behaviors. However, the effects of venlafaxine (Ven) on the …

Unraveling the enigma: housekeeping gene Ugt1a7c as a universal biomarker for microglia

W Kim, M Kim, B Kim - Frontiers in Psychiatry, 2024 - frontiersin.org
Background Microglia, brain resident macrophages, play multiple roles in maintaining
homeostasis, including immunity, surveillance, and protecting the central nervous system …