Sophisticated natural products as antibiotics

K Lewis, RE Lee, H Brötz-Oesterhelt, S Hiller… - Nature, 2024 - nature.com
In this Review, we explore natural product antibiotics that do more than simply inhibit an
active site of an essential enzyme. We review these compounds to provide inspiration for the …

[HTML][HTML] Phytogenic feed additives as natural antibiotic alternatives in animal health and production: A review of the literature of the last decade

J Wang, L Deng, M Chen, Y Che, L Li, L Zhu, G Chen… - Animal Nutrition, 2024 - Elsevier
The use of antibiotics in animal production raises great public safety concerns; therefore,
there is an urgent need for the development of substitutes for antibiotics. In recent decades …

The multiplicity of thioredoxin systems meets the specific lifestyles of Clostridia

C Anjou, A Lotoux, A Zhukova, M Royer… - PLoS …, 2024 - journals.plos.org
Cells are unceasingly confronted by oxidative stresses that oxidize proteins on their
cysteines. The thioredoxin (Trx) system, which is a ubiquitous system for thiol and protein …

[HTML][HTML] Insight into the Role of Gut Microbiota in Duchenne Muscular Dystrophy: An Age-Related Study in Mdx Mice

M Jollet, M Mariadassou, O Rué, L Pessemesse… - The American Journal of …, 2024 - Elsevier
Dystrophin deficiency alters the sarcolemma structure, leading to muscle dystrophy, muscle
disuse, and ultimately death. Beyond limb muscle deficits, patients with Duchenne muscular …

Gut microbiome diversity within Clostridia is negatively associated with human obesity

L Salazar-Jaramillo, J de la Cuesta-Zuluaga… - …, 2024 - journals.asm.org
Clostridia are abundant in the human gut and comprise families associated with host health
such as Oscillospiraceae, which has been correlated with leanness. However, culturing …

Clostridium Bacteria: Harnessing Tumour Necrosis for Targeted Gene Delivery

J Theys, AV Patterson, AM Mowday - Molecular Diagnosis & Therapy, 2024 - Springer
Necrosis is a common feature of solid tumours that offers a unique opportunity for targeted
cancer therapy as it is absent from normal healthy tissues. Tumour necrosis provides an …

Commensal antimicrobial resistance mediates microbiome resilience to antibiotic disruption

SK Bhattarai, M Du, AL Zeamer, B M. Morzfeld… - Science translational …, 2024 - science.org
Despite their therapeutic benefits, antibiotics exert collateral damage on the microbiome and
promote antimicrobial resistance. However, the mechanisms governing microbiome …

[HTML][HTML] Fecal microbiota transplantation unveils sex-specific differences in a controlled cortical impact injury mouse model

T Pasam, MP Dandekar - Frontiers in Microbiology, 2024 - frontiersin.org
Introduction Contusion type of traumatic brain injury (TBI) is a major cause of locomotor
disability and mortality worldwide. While post-TBI deleterious consequences are influenced …

High-Energy Supplemental Feeding Shifts Gut Microbiota Composition and Function in Red Deer (Cervus elaphus)

P Zheng, W Gao, S Cong, L Leng, T Wang, L Shi - Animals, 2024 - mdpi.com
Simple Summary Dietary selection affects the survival and health of mammals under winter,
high-energy supplemental feeding (SF) is one of the commonly used strategies for captive …

Novel strategies for modulating the gut microbiome for cancer therapy

YS Cho, K Han, J Xu, JJ Moon - Advanced Drug Delivery Reviews, 2024 - Elsevier
Recent advancements in genomics, transcriptomics, and metabolomics have significantly
advanced our understanding of the human gut microbiome and its impact on the efficacy …