[HTML][HTML] Extracellular vesicles in degenerative retinal diseases: A new therapeutic paradigm
F Manai, A Smedowski, K Kaarniranta… - Journal of Controlled …, 2024 - Elsevier
Nanoscale extracellular vesicles (EVs), consisting of exomers, exosomes and microvesicles/
ectosomes, have been extensively investigated in the last 20 years, although their biological …
ectosomes, have been extensively investigated in the last 20 years, although their biological …
Smart Nanoscale Extracellular Vesicles in the Brain: Unveiling their Biology, Diagnostic Potential, and Therapeutic Applications
Information exchange is essential for the brain, where it communicates the physiological and
pathological signals to the periphery and vice versa. Extracellular vesicles (EVs) are a …
pathological signals to the periphery and vice versa. Extracellular vesicles (EVs) are a …
Effective treatment of optic neuropathies by intraocular delivery of MSC-sEVs through augmenting the G-CSF-macrophage pathway
W Yi, Y Xue, W Qing, Y Cao, L Zhou… - Proceedings of the …, 2024 - National Acad Sciences
Optic neuropathies, characterized by injury of retinal ganglion cell (RGC) axons of the optic
nerve, cause incurable blindness worldwide. Mesenchymal stem cell–derived small …
nerve, cause incurable blindness worldwide. Mesenchymal stem cell–derived small …
Proteomic profiling of mesenchymal stem cell‐derived extracellular vesicles: Impact of isolation methods on protein cargo
M Abyadeh, S Mirshahvaladi… - Journal of …, 2024 - Wiley Online Library
Extracellular vesicles (EVs) are nanosized vesicles with a lipid bilayer that are secreted by
cells and play a critical role in cell‐to‐cell communication. Despite the promising reports …
cells and play a critical role in cell‐to‐cell communication. Despite the promising reports …
Mesenchymal Stem Cell–Derived Exosomes in Various Chronic Liver Diseases: Hype or Hope?
L Zhu, Q Wang, M Guo, H Fang, T Li, Y Zhu… - Journal of …, 2024 - Taylor & Francis
Chronic liver conditions are associated with high mortality rates and have a large adverse
effect on human well-being as well as a significant financial burden. Currently, the only …
effect on human well-being as well as a significant financial burden. Currently, the only …
[HTML][HTML] Utilizing extracellular vesicles as a drug delivery system in glaucoma and RGC degeneration
E Durmaz, L Dribika, M Kutnyanszky, B Mead - Journal of Controlled …, 2024 - Elsevier
Retinal diseases are the leading cause of blindness, resulting in irreversible degeneration
and death of retinal neurons. One such cell type, the retinal ganglion cell (RGC), is …
and death of retinal neurons. One such cell type, the retinal ganglion cell (RGC), is …
Combined treatment of human mesenchymal stem cells and green tea extract on retinal ganglion cell regeneration in rats after optic nerve injury
Q Yang, Y Xu, X Bin, KP Chan, S Chen, Z Qian… - Experimental Eye …, 2024 - Elsevier
Retinal ganglion cell (RGC) death and axonal loss cause irreversible vision loss upon optic
nerve (ON) injury. We have independently demonstrated that mesenchymal stem cells …
nerve (ON) injury. We have independently demonstrated that mesenchymal stem cells …
Human lens epithelial-secreted exosomes attenuate ocular angiogenesis via inhibiting microglial activation
Y Wu, J Wang, T Pan, J Lei, Y Fan, J Wang, C Xu… - Experimental Eye …, 2024 - Elsevier
The lens is an avascular tissue, where epithelial cells (LECs) are the primary living cells.
The role of LECs-derived exosomes (LEC-exos) is largely unknown. In our study, we …
The role of LECs-derived exosomes (LEC-exos) is largely unknown. In our study, we …
[HTML][HTML] Mesenchymal stem cells for repairing glaucomatous optic nerve
BY Hu, M Xin, M Chen, P Yu… - International Journal of …, 2024 - ncbi.nlm.nih.gov
Glaucoma is a common and complex neurodegenerative disease characterized by
progressive loss of retinal ganglion cells (RGCs) and axons. Currently, there is no effective …
progressive loss of retinal ganglion cells (RGCs) and axons. Currently, there is no effective …