How multiscale curvature couples forces to cellular functions

M Luciano, C Tomba, A Roux, S Gabriele - Nature Reviews Physics, 2024 - nature.com
Among the physicochemical cues in the cellular microenvironment that orchestrate cell
processes, the different levels of curvature in the extracellular matrix and intrinsic to the …

Stiffness anisotropy coordinates supracellular contractility driving long-range myotube-ECM alignment

NP Skillin, BE Kirkpatrick, KM Herbert, BR Nelson… - Science …, 2024 - science.org
The ability of cells to organize into tissues with proper structure and function requires the
effective coordination of proliferation, migration, polarization, and differentiation across …

Emerging role of lncRNAs as mechanical signaling molecules in mechanotransduction and their association with Hippo-YAP signaling: a review

S Lin, X He, Y Wang, Y Chen, A Lin - Journal of Zhejiang University …, 2024 - Springer
Cells within tissues are subject to various mechanical forces, including hydrostatic pressure,
shear stress, compression, and tension. These mechanical stimuli can be converted into …

[HTML][HTML] Development of Muscle Tendon Junction in vitro Using Aligned Electrospun PCL Fibres

N Iwasaki, M Roldo, A Karali, A Sensini… - Engineered …, 2024 - Elsevier
The muscle tendon junction (MTJ) transmits the force generated by the muscle to the tendon
and ultimately to the bone. Tears and strains commonly occur at the MTJ where …

Aligned Nanofibers Promote Myoblast Polarization and Myogenesis through Activating Rac-Related Signaling Pathways

X Dong, S Su, Q Sun, P Wang, Q Hu… - … Biomaterials Science & …, 2024 - ACS Publications
The extracellular matrix (ECM) plays a crucial role in regulating cellular behaviors and
functions. However, the impact of ECM topography on muscle cell adhesion and …

Geometry-driven migration efficiency of autonomous epithelial cell clusters

E Vercruysse, DB Brückner, M Gómez-González… - Nature Physics, 2024 - nature.com
The directed migration of epithelial cell collectives through coordinated movements plays a
crucial role in various physiological processes and is increasingly understood at the level of …

Effect of 3D‐Printable Anisotropic Fibrous Hydrogels on Fabricating Artificial Skeletal Muscle Constructs

K Kim, S Jin, M Shin - Advanced Therapeutics, 2024 - Wiley Online Library
The use of fibrous hydrogel constructs is a promising strategy in tissue engineering because
of their ability to closely mimic the anisotropic structure of biological tissues. In skeletal …

[HTML][HTML] In vitro development of a muscle-tendon junction construct using decellularised extracellular matrix: Effect of cyclic tensile loading

N Iwasaki, M Roldo, A Karali, G Blunn - Biomaterials Advances, 2024 - Elsevier
The muscle tendon junction (MTJ) plays a crucial role in transmitting the force generated by
muscles to the tendon and then to the bone. Injuries such as tears and strains frequently …

Regulation of myogenic differentiation of myoblasts by groove structure for the design of cell culture meat scaffolds

Y Chen, W Dai, W Xiong, Y Zhou, Z Chen, C Ge… - Food Bioscience, 2024 - Elsevier
As a meat substitute, cell cultured meat aims to simulate the composition of real meat to
provide nutrient substance. The myotube formation efficiency of myoblasts in vitro is the key …

Sensing the squeeze: nuclear mechanotransduction in health and disease

LK Srivastava, AJ Ehrlicher - Nucleus, 2024 - Taylor & Francis
The nucleus not only is a repository for DNA but also a center of cellular and nuclear
mechanotransduction. From nuclear deformation to the interplay between mechanosensing …