Relevance of Multiple Sclerosis Severity Genotype in Predicting Disease Course: A Real‐World Cohort

KL Kreft, E Uzochukwu, S Loveless, M Willis… - Annals of …, 2024 - Wiley Online Library
Objective Currently, 233 genetic loci are known to be associated with susceptibility to
multiple sclerosis (MS). Two independent pivotal severity genome‐wide association studies …

Spontaneous human CD8 T cell and autoimmune encephalomyelitis-induced CD4/CD8 T cell lesions in the brain and spinal cord of HLA-DRB1* 15-positive multiple …

I Papazian, M Kourouvani, A Dagkonaki, V Gouzouasis… - eLife, 2024 - elifesciences.org
Autoimmune diseases of the central nervous system (CNS) such as multiple sclerosis (MS)
are only partially represented in current experimental models and the development of …

Genetic contribution to medium-term disease activity in multiple sclerosis

E Mascia, V Nale, L Ferrè, M Sorosina, F Clarelli… - Molecular …, 2024 - Springer
Multiple sclerosis (MS) is a complex disorder characterized by high heterogeneity in terms of
phenotypic expression, prognosis and treatment response. In the present study, we aimed to …

Adaptive and Innate Immunity Are Key Drivers of Age at Onset of Multiple Sclerosis

E Misicka, Y Huang, S Loomis, N Sadhu… - Neurology …, 2024 - AAN Enterprises
Background and Objectives Multiple sclerosis (MS) age at onset (AAO) is a clinical predictor
of long-term disease outcomes, independent of disease duration. Little is known about the …

Pediatric multiple sclerosis and acute disseminated encephalomyelitis

KA O'Neill, C Fernandez-Carbonell… - The Rose and Mackay …, 2024 - Elsevier
Multiple sclerosis (MS), commonly a disease of young adulthood, occurs in children and
adolescents at an estimated 2%–5% frequency in the MS population. Pediatric MS refers to …

Characterization of the Increase in Narcolepsy following the 2009 H1N1 Pandemic in Sweden

H Gauffin, I Boström, SG Berntsson… - Journal of Clinical …, 2024 - mdpi.com
(1) Background: In the context of the H1N1 pandemic and the Pandemrix vaccination
campaign, an increased number of narcolepsy cases were noted in several countries. In …

Neuropathology of Neurological Disorders

MA Rather, A Khan, H Javed, S Jahan… - Mechanism and Genetic …, 2024 - Springer
Neuropathology delineates the examination of cells and tissues, to assimilate the structure
and function of the neurological system as well as the diagnosis and pathology of diseases …

Metabolic control of neural stem cell function in a patient-derived model of multiple sclerosis

RB Ionescu - 2024 - repository.cam.ac.uk
Multiple sclerosis (MS), the most prevalent inflammatory autoimmune disorder affecting the
central nervous system (CNS), results in the deterioration of myelin sheaths and neuronal …