Design, synthesis, and antiproliferative activity of new indole/1, 2, 4‐triazole/chalcone hybrids as EGFR and/or c‐MET inhibitors
E Mahmoud, D Abdelhamid, BGM Youssif… - Archiv der …, 2024 - Wiley Online Library
A novel group of indolyl‐1, 2, 4‐triazole‐chalcone hybrids was designed, synthesized, and
assessed for their anticancer activity. The synthesized compounds exhibited significant …
assessed for their anticancer activity. The synthesized compounds exhibited significant …
Exploring the anti-Alzheimer potential: Design, synthesis, biological activity, and molecular docking study of benzothiazol-1, 3, 4-oxadiazole-acetamide compounds
In this research, a series of benzothiazol-1, 3, 4-oxadiazole-acetamide derivatives (7a–k)
were synthesized as potential therapeutic agents targeting Alzheimer's disease. The …
were synthesized as potential therapeutic agents targeting Alzheimer's disease. The …
Insight into role of triazole derived Schiff base bearing sulfonamide derivatives in targeting Alzheimer's disease: Synthesis, characterization, in vitro and in silico …
Abstract Alzheimer's disease (AD), a chronic neurodegenerative disorder is reported with its
high prevalence and increasing at a disturbing level across the world. Due to no availability …
high prevalence and increasing at a disturbing level across the world. Due to no availability …
Hybrid benzothiazole derived fused triazole/thiazole derivatives as versatile anti-Alzheimer agents: synthesis, characterization, biological evaluation and molecular …
Alzheimer's disease, as per reports, 50 million people worldwide suffer from dementia and
an increase of 152 million is expected by 2050. This study reports a novel synthetic …
an increase of 152 million is expected by 2050. This study reports a novel synthetic …
Efficient, rapid, and high‐yield synthesis of aryl Schiff base derivatives and their in vitro and in silico inhibition studies of hCA I, hCA II, AChE, and BuChE
This study reports a rapid and efficient synthesis of four novel aryl Schiff base derivatives.
Biological activity and molecular modeling studies were conducted to evaluate the inhibitory …
Biological activity and molecular modeling studies were conducted to evaluate the inhibitory …
Design, synthesis, and molecular docking studies of new phenanthrene-linked oxadiazoles as potential antimicrobial agents
R Thongolla, R Pulabala, SS Gogula… - Journal of Molecular …, 2024 - Elsevier
Oxadiazoles and phenanthrene-based tylophorine alkaloids exhibit diverse biological
activities, and the combination of both provides significant biological activity. Herein, we …
activities, and the combination of both provides significant biological activity. Herein, we …
[HTML][HTML] Synthesis, computational studies and evaluation of benzisoxazole tethered 1, 2, 4-triazoles as anticancer and antimicrobial agents
D Dwarakanath, A Kulal, B Basappa, Z Xi… - Journal of Molecular …, 2024 - Elsevier
A novel series of six compounds, benzisoxazole tethered 1, 2, 4-triazoles were synthesized
in five steps with good yields and characterized. 1 H NMR, 13 C NMR and mass …
in five steps with good yields and characterized. 1 H NMR, 13 C NMR and mass …
[HTML][HTML] Structure based design, synthesis of novel fused triazole-thiazole derivatives and their comparative study on Alzheimer disease along with in silico modeling
In this approach, fused triazole thiazole derivatives (1–14) were synthesized and designed
as dual inhibitors of AChE and BuChE which exhibit promising inhibitory activity to cure one …
as dual inhibitors of AChE and BuChE which exhibit promising inhibitory activity to cure one …
A Review on Emerging Impact of Antitubercular Activity of 1, 2, 4-Triazole Derivatives
V Rangaswamy, U Laddi - Anti-Infective Agents, 2024 - ingentaconnect.com
The present review aims to summarize the antitubercular profile of 1, 2, 4-triazole, one of the
emerging entitled and most sought scaffold with a wide spectrum of biological and …
emerging entitled and most sought scaffold with a wide spectrum of biological and …
TBAB in One-pot Green Approach for the Synthesis of N-Heterocyclic Compounds: A Comprehensive Review
Designing innovative one-pot reactions using eco-friendly methodologies has attracted a lot
of attention in drug development, organic synthesis, and material sciences due to the …
of attention in drug development, organic synthesis, and material sciences due to the …