Control of adaptive immunity by pattern recognition receptors
One of the most significant conceptual advances in immunology in recent history is the
recognition that signals from the innate immune system are required for induction of …
recognition that signals from the innate immune system are required for induction of …
Dendritic cells in cancer immunology and immunotherapy
L Hato, A Vizcay, I Eguren, JL Pérez-Gracia… - Cancers, 2024 - mdpi.com
Simple Summary Although immune check point inhibitors have been established as a new
paradigm in cancer treatment, they have shown no clinical benefit in immune excluded or …
paradigm in cancer treatment, they have shown no clinical benefit in immune excluded or …
The pore-forming apolipoprotein APOL7C drives phagosomal rupture and antigen cross-presentation by dendritic cells
GA Gonzales, S Huang, L Wilkinson, JA Nguyen… - Science …, 2024 - science.org
Conventional dendritic cells (cDCs) generate protective cytotoxic T lymphocyte (CTL)
responses against extracellular pathogens and tumors. This is achieved through a process …
responses against extracellular pathogens and tumors. This is achieved through a process …
[HTML][HTML] Heterozygous missense CSF1R variants hamper in vitro CD34+-derived dendritic cell generation but not in vivo dendritic cell development
S Beerepoot, NI Wolf, MS van der Knaap… - Molecular …, 2024 - Elsevier
Colony stimulating factor 1 receptor (CSF1R) is an essential receptor for both colony
stimulating factor 1 (CSF1) and interleukin (IL) 34 signaling expressed on monocyte …
stimulating factor 1 (CSF1) and interleukin (IL) 34 signaling expressed on monocyte …
Engineering dendritic cell biomimetic membrane as a delivery system for tumor targeted therapy
H Liu, Y Lu, J Zong, B Zhang, X Li, H Qi, T Yu… - Journal of …, 2024 - Springer
Targeted immunotherapies make substantial strides in clinical cancer care due to their
ability to counteract the tumor's capacity to suppress immune responses. Advances in …
ability to counteract the tumor's capacity to suppress immune responses. Advances in …
Dendritic cell subsets and implications for cancer immunotherapy
MY Chen, F Zhang, SP Goedegebuure… - Frontiers in …, 2024 - frontiersin.org
Dendritic cells (DCs) play a central role in the orchestration of effective T cell responses
against tumors. However, their functional behavior is context-dependent. DC type …
against tumors. However, their functional behavior is context-dependent. DC type …
The XCL1-Mediated DNA Vaccine Targeting Type 1 Conventional Dendritic Cells Combined with Gemcitabine and Anti-PD1 Antibody Induces Potent Antitumor …
K Zhang, Q Wuri, Z Cai, X Qu, S Zhang, H Wu… - International Journal of …, 2024 - mdpi.com
With the advent of cancer immunotherapy, there is a growing interest in vaccine
development as a means to activate the cellular immune system against cancer. Despite the …
development as a means to activate the cellular immune system against cancer. Despite the …
A Minimal PBPK/PD Model with Expansion-Enhanced Target-Mediated Drug Disposition to Support a First-in-Human Clinical Study Design for a FLT3L-Fc Molecule
I Hosseini, B Fleisher, J Getz, J Decalf, M Kwong… - Pharmaceutics, 2024 - mdpi.com
FLT3L-Fc is a half-life extended, effectorless Fc-fusion of the native human FLT3-ligand. In
cynomolgus monkeys, treatment with FLT3L-Fc leads to a complex pharmacokinetic …
cynomolgus monkeys, treatment with FLT3L-Fc leads to a complex pharmacokinetic …
Chemotactic signaling pathways in prostate cancer: Implications in the tumor microenvironment and as potential therapeutic targets
ZA Lopez-Bujanda, SH Hadavi… - … review of cell and …, 2024 - pubmed.ncbi.nlm.nih.gov
Prostate cancer (PCa) stands as a significant global health concern, ranking among the
leading causes of cancer deaths in men. While there are several treatment modalities for …
leading causes of cancer deaths in men. While there are several treatment modalities for …
Spatial architecture of CD8+ T cells and DC subsets is critical for the response to immune checkpoint inhibitors in melanoma
E Gobbini, M Hubert, AC Doffin, A Eberhardt, L Hermet… - bioRxiv, 2024 - biorxiv.org
Background: Dendritic cells (DCs) are promising targets for cancer immunotherapies owing
to their central role in the initiation and the control of immune responses. Their functions …
to their central role in the initiation and the control of immune responses. Their functions …