Type 2 diabetes mellitus (T2DM) is common and increasing in prevalence worldwide, with
devastating public health consequences. While peripheral insulin resistance is a key feature …

Abstract Purpose of Review This review examines the linked pathophysiology of Alzheimer's
disease/related dementia (AD/ADRD) and bone disorders like osteoporosis. The emphasis …

Some individuals are able to maintain their cognitive abilities despite the presence of
significant Alzheimer's Disease (AD) neuropathological changes. This discrepancy between …

Aim: The current work was designed to demonstrate the application of the exposome
framework in examining associations between exposures and children's long-term …

INTRODUCTION Human data suggest susceptibility and resilience to features of Alzheimer's
disease (AD) such as microglia activation and synaptic dysfunction are under genetic …

ZCCHC17 is a putative master regulator of synaptic gene dysfunction in Alzheimer's disease
(AD), and ZCCHC17 protein declines early in AD brain tissue, before significant gliosis or …

While the concept of cognitive resilience is well-established it has not been defined in a way
that can be measured. This has been an impediment to studying its underlying biology and …

INTRODUCTION In 2013, the ALzheimer's and FAmilies (ALFA) project was established to
investigate pathophysiological changes in preclinical Alzheimer's disease (AD), and to foster …

Background Cognitive impairment and psychological resilience are closely related in older
adults, but their combined effect on mortality has not been reported. Using a nationally …

Elucidating the mechanisms by which late-life neurodegeneration causes cognitive decline
requires understanding why some individuals are more resilient than others to the effects of …