[HTML][HTML] State of the science on brain insulin resistance and cognitive decline due to Alzheimer's disease
Type 2 diabetes mellitus (T2DM) is common and increasing in prevalence worldwide, with
devastating public health consequences. While peripheral insulin resistance is a key feature …
devastating public health consequences. While peripheral insulin resistance is a key feature …
Mind the gap: unraveling the intricate dance between Alzheimer's disease and related dementias and bone health
Abstract Purpose of Review This review examines the linked pathophysiology of Alzheimer's
disease/related dementia (AD/ADRD) and bone disorders like osteoporosis. The emphasis …
disease/related dementia (AD/ADRD) and bone disorders like osteoporosis. The emphasis …
The concept of resilience to Alzheimer's Disease: current definitions and cellular and molecular mechanisms
LE de Vries, I Huitinga, HW Kessels, DF Swaab… - Molecular …, 2024 - Springer
Some individuals are able to maintain their cognitive abilities despite the presence of
significant Alzheimer's Disease (AD) neuropathological changes. This discrepancy between …
significant Alzheimer's Disease (AD) neuropathological changes. This discrepancy between …
Toward a more holistic approach to the study of exposures and child outcomes
Aim: The current work was designed to demonstrate the application of the exposome
framework in examining associations between exposures and children's long-term …
framework in examining associations between exposures and children's long-term …
Control of hippocampal synaptic plasticity by microglia–dendrite interactions depends on genetic context in mouse models of Alzheimer's disease
SE Heuer, KJ Keezer, AA Hewes… - Alzheimer's & …, 2024 - Wiley Online Library
INTRODUCTION Human data suggest susceptibility and resilience to features of Alzheimer's
disease (AD) such as microglia activation and synaptic dysfunction are under genetic …
disease (AD) such as microglia activation and synaptic dysfunction are under genetic …
ZCCHC17 modulates neuronal RNA splicing and supports cognitive resilience in Alzheimer's disease
AMW Bartosch, EHH Youth, S Hansen… - Journal of …, 2024 - Soc Neuroscience
ZCCHC17 is a putative master regulator of synaptic gene dysfunction in Alzheimer's disease
(AD), and ZCCHC17 protein declines early in AD brain tissue, before significant gliosis or …
(AD), and ZCCHC17 protein declines early in AD brain tissue, before significant gliosis or …
From theory to practice: translating the concept of cognitive resilience to novel therapeutic targets that maintain cognition in aging adults
AR Zammit, DA Bennett, AS Buchman - Frontiers in Aging …, 2024 - frontiersin.org
While the concept of cognitive resilience is well-established it has not been defined in a way
that can be measured. This has been an impediment to studying its underlying biology and …
that can be measured. This has been an impediment to studying its underlying biology and …
Genetic characterization of the ALFA study: Uncovering genetic profiles in the Alzheimer's continuum
N Vilor‐Tejedor, P Genius… - Alzheimer's & …, 2024 - Wiley Online Library
INTRODUCTION In 2013, the ALzheimer's and FAmilies (ALFA) project was established to
investigate pathophysiological changes in preclinical Alzheimer's disease (AD), and to foster …
investigate pathophysiological changes in preclinical Alzheimer's disease (AD), and to foster …
Combined associations of cognitive impairment and psychological resilience with all-cause mortality in community-dwelling older adults
C Zhang, Y Liu, L Zeng, X Luo, G Fan, H Shi… - Journal of Affective …, 2024 - Elsevier
Background Cognitive impairment and psychological resilience are closely related in older
adults, but their combined effect on mortality has not been reported. Using a nationally …
adults, but their combined effect on mortality has not been reported. Using a nationally …
Development of a machine learning algorithm to predict the residual cognitive reserve index
BE Gavett, S Tomaszewski Farias… - Brain …, 2024 - academic.oup.com
Elucidating the mechanisms by which late-life neurodegeneration causes cognitive decline
requires understanding why some individuals are more resilient than others to the effects of …
requires understanding why some individuals are more resilient than others to the effects of …