Bladder cancer is a histologically and clinically heterogenous disease. Most bladder
cancers are urothelial carcinomas, which frequently develop distinct histological subtypes …

The urothelium is a stratified epithelium composed of basal cells, one or more layers of
intermediate cells, and an upper layer of differentiated umbrella cells. Most bladder cancers …

The combination of targeted therapy with immune checkpoint inhibition (ICI) is an area of
intense interest. We studied the interaction of fibroblast growth factor receptor (FGFR) …

Abstract CDK4/6 inhibitors (CDK4/6i) show anticancer activity in certain human
malignancies, such as breast cancer. However, their application to other tumor types and …

Activation of the p53 tumor suppressor triggers a transcriptional program to control cellular
response to stress. However, the molecular mechanisms by which p53 controls gene …

Urine is a complex biofluid that reflects both overall physiologic state and the state of the
genitourinary tissues through which it passes. It contains both secreted proteins and proteins …

Background SMC1A is a subunit of the cohesin complex that participates in many DNA-and
chromosome-related biological processes. Previous studies have established that SMC1A is …

Seven cases of primary lung tumors characterized histologically by clear cell morphology
and a distinctive FGFR3:: TACC3 gene rearrangement are described. The tumors arose in 4 …

Background Bladder cancer is one of the most common cancer types worldwide. Generally,
research relies on invasive sampling strategies. Methods Here, we generate bladder cancer …

The differences in bladder cancer outcomes between the sexes has again been highlighted.
Uncommon among cancers, bladder cancer outcomes are notably worse for women than for …