[HTML][HTML] Unravelling the role of HAS2, GREM1, and PTGS2 gene expression in cumulus cells: implications for human oocyte development competency-a systematic …

AM Faizal, MH Elias, NM Jin, MA Abu… - Frontiers in …, 2024 - ncbi.nlm.nih.gov
The leading indicator for successful outcomes in in-vitro fertilization (IVF) is the quality of
gametes in oocytes and sperm. Thus, advanced research aims to highlight the parameter in …

Advances in the discovery of activin receptor-like kinase 5 (ALK5) inhibitors

MA Mansour, GS Hassan, RAT Serya, MY Jaballah… - Bioorganic …, 2024 - Elsevier
Abstract Activin receptor‑like kinase-5 (ALK5) is an outstanding member of the transforming
growth factor-β (TGF-β) family.(TGF-β) signaling pathway integrates pleiotropic proteins that …

A rare germline BMP15 missense mutation causes hereditary ovarian immature teratoma in human

Y Liu, H Fan, X Kang, Y Hao, N Wang… - Proceedings of the …, 2024 - National Acad Sciences
Ovarian immature teratomas (OITs) are malignant tumors originating from the ovarian germ
cells that mainly occur during the first 30 y of a female's life. Early age of onset strongly …

Oocyte and cumulus cell cooperativity and metabolic plasticity under the direction of oocyte paracrine factors

D Richani, A Poljak, B Wang… - American Journal …, 2024 - journals.physiology.org
Mammalian oocytes develop and mature in a mutually dependent relationship with
surrounding cumulus cells. The oocyte actively regulates cumulus cell differentiation and …

[HTML][HTML] Unravelling the role of HAS2, GREM1, and PTGS2 gene expression in cumulus cells: implications for human oocyte development competency-a systematic …

AM Faizal, MH Elias, NM Jin, MA Abu… - Frontiers in …, 2024 - frontiersin.org
The leading indicator for successful outcomes in in-vitro fertilization (IVF) is the quality of
gametes in oocytes and sperm. Thus, advanced research aims to highlight the parameter in …

[HTML][HTML] Polymorphisms of the BMPR1B, BMP15 and GDF9 fecundity genes in four Chinese sheep breeds

J Wang, Y Liu, S Guo, R Di, X Wang… - Archives Animal …, 2024 - aab.copernicus.org
Numerous studies on prolific sheep breeds have shown that the transforming growth factor
beta (TGF-β) superfamily members, including bone morphogenetic protein receptor type 1B …

Reconstruction of ovarian follicular-like structure by recellularization of a cell-free human ovarian scaffold with mouse fetal ovarian cells

MN Sistani, S Zavareh, MR Valojerdi, M Salehnia - Cytotechnology, 2024 - Springer
The present study assessed the supportive roles of the decellularized human ovarian tissue
in homing of mouse fetal ovarian cells into the scaffold as well as the formation of the …

Characterization of the molecular mechanisms that govern anti‐Müllerian hormone synthesis and activity

WA Stocker, JA Howard, S Maskey, H Luan… - The FASEB …, 2024 - Wiley Online Library
The roles of anti‐Müllerian hormone (AMH) continue to expand, from its discovery as a
critical factor in sex determination, through its identification as a regulator of ovarian …

经后增殖方对控制性超促排卵大鼠卵巢GDF9 分泌及颗粒细胞凋亡的影响

杨贞, 江少如, 陈小燕, 陈晓琳, 邓伟民, 郭新宇 - 实用医学杂志, 2024 - syyxzz.com
目的观察益气血法经后增殖方通过p38MAPK/CK2/IκBα/NF-κB 通路对控制性超促排卵(COH)
大鼠卵巢GDF9 分泌及颗粒细胞(GCs) 凋亡的影响. 方法建立COH 大鼠模型, 18 …

The expression patterns of different cell types and their interactions in the tumor microenvironment are predictive of breast cancer patient response to neoadjuvant …

SR Dhruba, S Sahni, B Wang, D Wu, PS Rajagopal… - bioRxiv, 2024 - biorxiv.org
The tumor microenvironment (TME) is a complex ecosystem of diverse cell types whose
interactions govern tumor growth and clinical outcome. While the TME's impact on …