Synthetic cell factory offers substantial advantages in economically efficient production of
biofuels, chemicals, and pharmaceutical compounds. However, to create a high …

Genome engineering has revolutionized several scientific fields, ranging from biochemistry
and fundamental research to therapeutic uses and crop development. Diverse engineering …

Performing saturation editing of chromosomal genes will enable the study of genetic variants
in situ and facilitate protein and cell engineering. However, current in vivo editing of …

Estrogen receptor α is commonly used in synthetic biology to control the activity of genome
editing tools. The activating ligands, estrogens, however, interfere with various cellular …

The engineering of microbial cell factories for the production of high-value chemicals from
renewable resources presents several challenges, including the optimization of key …

Directed evolution is a powerful method in biological engineering. Current approaches draw
on time-invariant selection mechanisms, ideal for evolving steady-state properties such as …

Provided are methods comprising expressing in a recombinant cell a recombinant error-
prone reverse transcriptase (RT) and recombinant spacer RNA comprising a target …

US20240035052A1 - Compositions and methods for metabolic control of a biofermentation
process with synthetic metabolic valves - Google Patents US20240035052A1 …

The natural process of evolutionary adaptation is often exploited as a powerful tool to obtain
microbes with desirable traits. For industrial microbes, evolutionary engineering is often …