[HTML][HTML] Mitochondrial dysfunction: mechanisms and advances in therapy
Y Zong, H Li, P Liao, L Chen, Y Pan, Y Zheng… - … and Targeted Therapy, 2024 - nature.com
Mitochondria, with their intricate networks of functions and information processing, are
pivotal in both health regulation and disease progression. Particularly, mitochondrial …
pivotal in both health regulation and disease progression. Particularly, mitochondrial …
[HTML][HTML] Mitochondrial network dynamics in pulmonary disease: Bridging the gap between inflammation, oxidative stress, and bioenergetics
MD Pokharel, A Garcia-Flores, D Marciano, MC Franco… - Redox Biology, 2024 - Elsevier
Once thought of in terms of bioenergetics, mitochondria are now widely accepted as both the
orchestrator of cellular health and the gatekeeper of cell death. The pulmonary disease field …
orchestrator of cellular health and the gatekeeper of cell death. The pulmonary disease field …
[HTML][HTML] Hyperglycemia triggers RyR2-dependent alterations of mitochondrial calcium homeostasis in response to cardiac ischemia-reperfusion: Key role of DRP1 …
M Dubois, D Boulghobra, G Rochebloine, F Pallot… - Redox Biology, 2024 - Elsevier
Hyperglycemia increases the heart sensitivity to ischemia-reperfusion (IR), but the
underlying cellular mechanisms remain unclear. Mitochondrial dynamics (the processes that …
underlying cellular mechanisms remain unclear. Mitochondrial dynamics (the processes that …
[HTML][HTML] Inhibition of Drp1-Fis1 interaction alleviates aberrant mitochondrial fragmentation and acute kidney injury
Z Song, Y Xia, L Shi, H Zha, J Huang, X Xiang… - Cellular & Molecular …, 2024 - Springer
Background Acute kidney injury (AKI) is a common clinical disorder with complex etiology
and poor prognosis, and currently lacks specific and effective treatment options …
and poor prognosis, and currently lacks specific and effective treatment options …
Is mitochondrial morphology important for cellular physiology?
T Wai - Trends in Endocrinology & Metabolism, 2024 - cell.com
Mitochondria are double membrane-bound organelles the network morphology of which in
cells is shaped by opposing events of fusion and fission executed by dynamin-like GTPases …
cells is shaped by opposing events of fusion and fission executed by dynamin-like GTPases …
Differential Efficacy of Small Molecules Dynasore and Mdivi-1 for the Treatment of Dry Eye Epitheliopathy or as a Countermeasure for Nitrogen Mustard Exposure of …
J Pan, S Pany, R Martinez-Carrasco, ME Fini - Journal of Pharmacology and …, 2024 - ASPET
The ocular surface comprises the wet mucosal epithelia of the cornea and conjunctiva, the
associated glands, and the overlying tear film. Epitheliopathy is the common pathologic …
associated glands, and the overlying tear film. Epitheliopathy is the common pathologic …
The mitochondrial fission protein DRP1 influences memory CD8+ T cell formation and function
MG Stevens, FM Mason… - Journal of Leukocyte …, 2024 - academic.oup.com
Pharmacological methods for promoting mitochondrial elongation suggest that effector T
cells can be altered to support a memory T cell–like metabolic state. Such mitochondrial …
cells can be altered to support a memory T cell–like metabolic state. Such mitochondrial …
[HTML][HTML] ISGylation of DRP1 closely balances other post-translational modifications to mediate mitochondrial fission
P Das, O Chakrabarti - Cell Death & Disease, 2024 - nature.com
Abstract Dynamin related protein 1 (DRP1), a pivotal mitochondrial fission protein, is post-
translationally modified by multiple mechanisms. Here we identify a new post-translational …
translationally modified by multiple mechanisms. Here we identify a new post-translational …
Mitochondrial fission inhibition protects against hypertension induced by angiotensin II
KJ Preston, T Kawai, K Torimoto, R Kuroda… - Hypertension …, 2024 - nature.com
Mitochondrial dysfunction has been implicated in various types of cardiovascular disease
including hypertension. Mitochondrial fission fusion balance is critical to mitochondrial …
including hypertension. Mitochondrial fission fusion balance is critical to mitochondrial …
[HTML][HTML] Mitochondrial division inhibitor (mdivi-1) induces extracellular matrix (ECM)-detachment of viable breast cancer cells by a DRP1-independent mechanism
E Silva-Pavez, E Mendoza, P Morgado-Cáceres… - Scientific Reports, 2024 - nature.com
Increasing evidence supports the hypothesis that cancer progression is under mitochondrial
control. Mitochondrial fission plays a pivotal role in the maintenance of cancer cell …
control. Mitochondrial fission plays a pivotal role in the maintenance of cancer cell …