This is a narrative review of the published evidence for bleeding management in critically ill
patients in different clinical settings in the intensive care unit (ICU). We aimed to describe …

Traumatic brain injury is one of the leading causes of morbidity and mortality worldwide and
is one of the major public healthcare burdens in the US, with millions of patients suffering …

Injury mechanism is an important consideration when conducting clinical trials in trauma.
Mechanisms of injury may be associated with differences in mortality risk and immune …

Background Tranexamic acid (TXA) has been hypothesized to mitigate coagulopathy in
patients after traumatic injury. Despite previous prehospital clinical trials demonstrating a …

Injury remains a significant global health concern, with early major haemorrhage (MH) being
a leading cause of preventable death. However, the absence of a standardised definition for …

Trauma-induced coagulopathy (TIC) is a global inflammatory state accompanied by
coagulation derangements, acidemia, and hypothermia, which occurs after traumatic injury …

Interplay between platelets, coagulation factors, endothelial cells (ECs), and fibrinolytic
factors is necessary for effective hemostatic plug formation. This study describes a 4 …

Cardiomyopathies encompass a spectrum of heart disorders with diverse causes and
presentations. Fibrosis stands out as a shared hallmark among various cardiomyopathies …

Two-sample MR is an increasingly popular method for strengthening causal inference in
epidemiological studies. For the effect estimates to be meaningful, variant-exposure and …

Background: Postpartum hemorrhage remains a leading cause of maternal mortality
especially in developing countries. The majority of previous trials on the effectiveness of …