Exosomes are the smallest subset of extracellular signaling vesicles secreted by most cells
with the ability to communicate with other tissues and cell types over long distances. Their …

β-cell death contributes to β-cell loss and insulin insufficiency in type 1 diabetes (T1D), and
this β-cell demise has been attributed to apoptosis and necrosis. Apoptosis has been …

Diabetes mellitus (DM) is a chronic disease that occurs when the body cannot produce or
use insulin properly. It is considered one of the most prevalent and fastest-growing diseases …

Background Peripheral insulin resistance and compromised insulin secretion from
pancreatic β-cells are significant factors and pathogenic hallmarks of diabetes mellitus (DM) …

Mesenchymal stem/stromal cells (MSCs) are emerging as a new therapy for diabetes. Here
we investigate the properties of MSCs engineered to express Islet Neogenesis Associated …

Residual beta cells are present in most patients with longstanding type 1 diabetes but it is
unknown whether these beta cells react normally to different stimuli. Moreover a defect in …

Nowadays, the focus of diabetes treatment has switched from lowering the glucose level to
preserving glycemic homeostasis and slowing the disease progression. The main …

The sympathetic nervous system is crucial for the regulation of visceral organ function. For
instance, the activation of the sympathetic nervous system promotes glycogenolysis in the …

Aims The existence of insulin-or glucagon-expressing extra-islet endocrine cells scattered in
the pancreas is well-known, but they have been sparsely characterized. The aim of this …

Introduction and purpose: Diabetes has emerged as a global lifestyle disease, with an
alarming rise in cases, particularly of type 2 diabetes. In Poland, over 3 million people are …