Atherosclerosis, which currently contributes to 31% of deaths globally, is of critical
cardiovascular concern. Current diagnostic tools and biomarkers are limited, emphasizing …

Cellular metabolism encompasses a complex array of interconnected biochemical pathways
that are required for cellular homeostasis. When dysregulated, metabolism underlies …

Glioblastoma (GBM) is a malignancy dominated by the infiltration of tumor-associated
myeloid cells (TAMCs). Examination of TAMC metabolic phenotypes in mouse models and …

Mapping the ligandability or potential druggability of all proteins in the human proteome is a
central goal of mass spectrometry-based covalent chemoproteomics. Achieving this …

The complexity of macrophage (MΦ) plasticity and polarization states, which include
classically activated pro-inflammatory (M1) and alternatively activated anti-inflammatory …

Immunoglobulin E (IgE)‐mediated food allergy is a rapidly growing public health problem.
The interaction between allergens and IgE is at the core of the allergic response. One of the …

Redox signaling, a mode of signal transduction that involves the transfer of electrons from a
nucleophilic to electrophilic molecule, has emerged as an essential regulator of …

Metabolic reprogramming is a hallmark of cancer, enabling cancer cells to rapidly
proliferate, invade, and metastasize. We show that creatine levels in metastatic breast …

Cysteines are amenable to a diverse set of modifications that exhibit critical regulatory
functions over the proteome and thereby control a wide range of cellular processes …

An important consideration in drug discovery is the prioritization of tractable protein targets
that are not only amenable to binding small molecules, but also alter disease biology in …