Hepatitis E virus: from innate sensing to adaptive immune responses

Y Brüggemann, M Klöhn, H Wedemeyer… - Nature Reviews …, 2024 - nature.com
Hepatitis E virus (HEV) infections are a major cause of acute viral hepatitis in humans
worldwide. In immunocompetent individuals, the majority of HEV infections remain …

Hepatitis E virus immunosuppressed animal models

KK Yadav, SP Kenney - BMC Infectious Diseases, 2024 - Springer
Hepatitis E virus (HEV) is an important emerging pathogen producing significant morbidity in
immunosuppressed patients. HEV has been detrimental to solid organ transplant (SOT) …

Genetic determinants of host-and virus-derived insertions for hepatitis E virus replication

MH Wißing, TL Meister, MK Nocke, A Gömer… - Nature …, 2024 - nature.com
Hepatitis E virus (HEV) is a long-neglected RNA virus and the major causative agent of
acute viral hepatitis in humans. Recent data suggest that HEV has a very heterogeneous …

Infectious hepatitis E virus excreted into the vagina

C Cong, Y Xia, S Gong, T Li, H Liu, G Zhong… - The FASEB …, 2024 - Wiley Online Library
Hepatitis E virus (HEV) persists in the male genital tract that associates with infertility.
However, the presence of HEV in the female genital tract is unreported. Vaginal secretions …

Optimization of immunosuppression strategies for the establishment of chronic hepatitis E virus infection in rabbits

Q He, T Liu, X Yang, D Yuan, Q Lu, Y Li… - Journal of …, 2024 - Am Soc Microbiol
Chronic hepatitis E mostly occurs in organ transplant recipients and can lead to rapid liver
fibrosis and cirrhosis. Previous studies found that the development of chronic hepatitis E …

[HTML][HTML] Combining RNA Interference and RIG-I Activation to Inhibit Hepatitis E Virus Replication

M Ziersch, D Harms, L Neumair, A Kurreck, R Johne… - Viruses, 2024 - mdpi.com
Hepatitis E virus (HEV) poses a significant global health threat, with an estimated 20 million
infections occurring annually. Despite being a self-limiting illness, in most cases, HEV …

From discovery to treatment: tracing the path of hepatitis E virus

A Letafati, Z Taghiabadi, M Roushanzamir… - Virology journal, 2024 - Springer
The hepatitis E virus (HEV) is a major cause of acute viral hepatitis worldwide. HEV is
classified into eight genotypes, labeled HEV-1 through HEV-8. Genotypes 1 and 2 …

[HTML][HTML] Pathogenesis and clinical features of severe hepatitis E virus infection

L Orosz, KP Sárvári, Á Dernovics… - World Journal of …, 2024 - ncbi.nlm.nih.gov
The hepatitis E virus (HEV), a member of the Hepeviridae family, is a small, non-enveloped
icosahedral virus divided into eight distinct genotypes (HEV-1 to HEV-8). Only genotypes 1 …

Hepatitis E Vaccines Updates

C Hartley, P Wasuwanich, T Van, W Karnsakul - Vaccines, 2024 - mdpi.com
The development of a hepatitis E vaccine is imperative given its prevalence and the
heightened risk it poses to specific populations. Hepatitis E virus infection, though often self …

Viral hepatitis A and E

J Zhu, Z Feng - Molecular Medical Microbiology, 2024 - Elsevier
Hepatitis A and E remain a major threat to public health in the world. The etiologic agents
responsible for these diseases are hepatitis A virus (HAV) and hepatitis E virus (HEV) …