[HTML][HTML] Readthrough Activators and Nonsense-Mediated mRNA Decay Inhibitor Molecules: Real Potential in Many Genetic Diseases Harboring Premature …

N Benslimane, C Loret, P Chazelas, F Favreau… - Pharmaceuticals, 2024 - mdpi.com
Nonsense mutations that generate a premature termination codon (PTC) can induce both
the accelerated degradation of mutated mRNA compared with the wild type version of the …

Messenger RNA Surveillance: Current Understanding, Regulatory Mechanisms, and Future Implications

R Das, GK Panigrahi - Molecular Biotechnology, 2024 - Springer
Nonsense-mediated mRNA decay (NMD) is an evolutionarily conserved surveillance
mechanism in eukaryotes primarily deployed to ensure RNA quality control by eliminating …