Genetic abnormalities play a crucial role in the development of neurodegenerative disorders
(NDDs). Genetic exploration has indeed contributed to unraveling the molecular …

This study aims to perform an extensive review of the literature that evaluates various factors
that affect the survival rates of patients with severe combined immunodeficiency (SCID) after …

Virus-specific T cells (VST) from partially-HLA matched donors have been effective for
treatment of refractory viral infections in immunocompromised patients in prior studies with a …

Idiopathic pulmonary fibrosis is a major cause of death with few treatment options. Here, we
demonstrate the therapeutic efficacy for lung fibrosis of adult lung cell transplantation using …

Viral infections remain a major risk in immunocompromised pediatric patients, and virus-
specific T cell (VST) therapy has been successful for treatment of refractory viral infections in …

Recombination-activating genes (RAG1 and RAG2) are critical for lymphoid cell
development and function by initiating the variable (V), diversity (D), and joining (J)(V (D) J) …

Umbilical cord blood (UCB) is a valuable source of hematopoietic stem cells (HSCs) used
for transplantation; the number of cells in a single UCB is too small to quickly establish bone …

Background Infections are a major cause for morbidity in children with primary or secondary
immunodeficiency, and have a negative impact on overall outcome. Objectives This …

Inborn errors of immunity (IEIs) encompass a diverse spectrum of genetic disorders that
disrupt the intricate mechanisms of the immune system, leading to a variety of clinical …

Background Many newborn screening programs worldwide have introduced screening for
diseases using DNA extracted from dried blood spots (DBS). In Germany, DNA-based …