MG53/TRIM72: multi-organ repair protein and beyond

YF Wang, ZY An, JW Li, ZK Dong, WL Jin - Frontiers in Physiology, 2024 - frontiersin.org
MG53, a member of the tripartite motif protein family, possesses multiple functionalities due
to its classic membrane repair function, anti-inflammatory ability, and E3 ubiquitin ligase …

MG53: A new protagonist in the precise treatment of cardiomyopathies

Q Zhao, Q Zhang, X Zhao, Z Tian, M Sun… - Biochemical Pharmacology, 2024 - Elsevier
Cardiomyopathies (CMs) are highly heterogeneous progressive heart diseases
characterised by structural and functional abnormalities of the heart, whose intricate …

Deciphering the role of the hendecad-repeat coiled-coil domain of TRIM72 in membrane curvature recognition

HK Song, SH Park - 2024 - researchsquare.com
RING-type E3 ubiquitin ligases are functional multidomain proteins involved in diverse
eukaryotic cellular processes. A major subfamily of RING-type ligases is the tripartite motif …

The effect of MG53 for modulating TGF-β1/Smad pathway in the nasal epithelial repair of nasal polyps.

D An, X Jiang, X Jiang, Y Jiang, M Pan, J Liu, X Ke… - Authorea …, 2024 - techrxiv.org
Background: The occurrence of nasal polyps is related to mucosal barrier damage. The role
of MG53, an important epithelial repair regulator, in nasal polyps remains unclear. This study …