Genetics of human longevity: From variants to genes to pathways
L Smulders, J Deelen - Journal of Internal Medicine, 2024 - Wiley Online Library
The current increase in lifespan without an equivalent increase in healthspan poses a grave
challenge to the healthcare system and a severe burden on society. However, some …
challenge to the healthcare system and a severe burden on society. However, some …
Associations of mitochondrial genomic variation with successful neurological aging
N Tamvaka, MG Heckman, PW Johnson… - Mitochondrion, 2024 - Elsevier
Mitochondrial health is an integral factor in aging, with mitochondrial dysfunction known to
increase with age and contribute to the development of age-related neurodegenerative …
increase with age and contribute to the development of age-related neurodegenerative …
[HTML][HTML] A variant in the 5′UTR of ERBB4 is associated with lifespan in Golden Retrievers
RB Rebhun, D York, FMD De Graaf, P Yoon… - GeroScience, 2024 - Springer
Genome-wide association studies (GWAS) in long-lived human populations have led to
identification of variants associated with Alzheimer's disease and cardiovascular disease …
identification of variants associated with Alzheimer's disease and cardiovascular disease …
Genetic predisposition, modifiable lifestyles, and their joint effects on human lifespan: evidence from multiple cohort studies
Z Bian, L Wang, R Fan, J Sun, L Yu, M Xu… - BMJ evidence-based …, 2024 - ebm.bmj.com
Objective To investigate the associations across genetic and lifestyle factors with lifespan.
Design A longitudinal cohort study. Setting UK Biobank. Participants 353 742 adults of …
Design A longitudinal cohort study. Setting UK Biobank. Participants 353 742 adults of …
Large-scale genome-wide interaction analyses on multiple cardiometabolic risk factors to identify age-specific genetic risk factors
L Ao, D van Heemst, J Luo, M Teder-Laving, R Mägi… - medRxiv, 2024 - medrxiv.org
Background: The genetic landscape of cardiometabolic risk factors has been explored
extensively. However, insight in the effects of genetic variation on these risk factors over the …
extensively. However, insight in the effects of genetic variation on these risk factors over the …
Natural Variation Reveals the SIRT6 C-Terminus as a Key Regulator of Pro-Longevity Activity
JM Gigas - 2024 - search.proquest.com
Aging is the process by which biological organisms decay over time, culminating in death.
Lifespan is a genetically regulated trait that is selected in response to environmental …
Lifespan is a genetically regulated trait that is selected in response to environmental …