Tumor location matters, next generation sequencing mutation profiling of left-sided, rectal, and right-sided colorectal tumors in 552 patients
I Ciepiela, M Szczepaniak, P Ciepiela… - Scientific Reports, 2024 - nature.com
Despite the introduction of new molecular classifications, advanced colorectal cancer (CRC)
is treated with chemotherapy supplemented with anti-EGFR and anti-VEGF targeted therapy …
is treated with chemotherapy supplemented with anti-EGFR and anti-VEGF targeted therapy …
Distinct Driver Pathway Enrichments and a High Prevalence of TSC2 Mutations in Right Colon Cancer in Chile: A Preliminary Comparative Analysis
C Tapia-Valladares, G Valenzuela, E González… - International Journal of …, 2024 - mdpi.com
Colorectal cancer (CRC) is the second leading cause of cancer deaths globally. While
ethnic differences in driver gene mutations have been documented, the South American …
ethnic differences in driver gene mutations have been documented, the South American …
Targeting MEK/COX-2 axis improve immunotherapy efficacy in dMMR colorectal cancer with PIK3CA overexpression
K Peng, Y Liu, S Liu, Z Wang, H Zhang, W He, Y Jin… - Cellular Oncology, 2024 - Springer
Purpose PIK3CA mutation or overexpression is associated with immunotherapy resistance
in multiple cancer types, but is also paradoxically associated with benefit of COX-2 inhibition …
in multiple cancer types, but is also paradoxically associated with benefit of COX-2 inhibition …
Molecular testing in colorectal cancer
JS Thomas, C Shi - Diagnostic molecular pathology, 2024 - Elsevier
Colorectal cancer (CRC) is a complex disease, in which at least three distinct molecular
pathways to carcinogenesis and four consensus molecular subtypes have been described …
pathways to carcinogenesis and four consensus molecular subtypes have been described …
Current drug therapy for colorectal cancer
Colorectal cancer (CRC) is characterized by a cancerous growth onto the internal lining of
the colon along with the rectum and large intestine. Long-time standard treatments for …
the colon along with the rectum and large intestine. Long-time standard treatments for …
[PDF][PDF] Clinical-pathological Profile of Colorectal Adenocarcinomas with APC, PIK3CA and SMAD4 Mutations in Uganda
R Wismayer, R Mathews, C Whalley, J Kiwanuka… - 2024 - researchgate.net
Introduction: APC gene mutations are an important initiator in tumorigenesis and have been
detected in many colorectal cancers (CRC). There is conflicting evidence regarding the …
detected in many colorectal cancers (CRC). There is conflicting evidence regarding the …
[PDF][PDF] COLON CANCER AND ITS TREATMENT
A Mandal, SM Gavade, CS Biswas, N Kavyashree… - mattioli1885journal.com
Colon cancer, a major contributor to cancer-related morbidity and mortality, remains a global
health challenge. The most recent scientific discoveries and clinical developments in the …
health challenge. The most recent scientific discoveries and clinical developments in the …