Close negative correlation of local and circulating Dickkopf-1 and Sclerostin levels during human fracture healing

J Starlinger, J Santol, G Kaiser, K Sarahrudi - Scientific Reports, 2024 - nature.com
Wnt signaling is critically involved in fracture healing. Existing data predominantly relies on
rodent models. Here, we explored local and circulating Dickkopf-1 (DKK1) levels in patients …

Biomimetic Therapeutics for Bone Regeneration: A Perspective on Antiaging Strategies

J Miszuk, H Sun - Macromolecular bioscience, 2024 - Wiley Online Library
Advances in modern medicine and the significant reduction in infant mortality have steadily
increased the population's lifespan. As more and more people in the world grow older …

Stem Cells and Acellular Preparations in Bone Regeneration/Fracture Healing: Current Therapies and Future Directions

MG Brown, DJ Brady, KM Healy, KA Henry… - Cells, 2024 - mdpi.com
Bone/fracture healing is a complex process with different steps and four basic tissue layers
being affected: cortical bone, periosteum, fascial tissue surrounding the fracture, and bone …

Surgical suction filter-derived bone graft displays osteogenic mirna and mrna patterns

RVM Groven, JT Blokhuis, M Poeze… - European Journal of …, 2024 - Springer
Purpose Recently, a surgical suction filter device was introduced which aims at generating a
suction filter-derived bone grafting substitute (SF-BGS). The osteogenic capacity of this …

Magnetic Graphene Oxide Nanocomposites Boosts Craniomaxillofacial Bone Regeneration by Modulating circAars/miR-128-3p/SMAD5 Signaling Axis

Y He, L Zhang, S Huang, Y Tang, Y Li, H Li… - International Journal …, 2024 - Taylor & Francis
Background The ability of nanomaterials to induce osteogenic differentiation is limited,
which seriously imped the repair of craniomaxillofacial bone defect. Magnetic graphene …

Engineered Nanofibrillar Collagen with Tunable Biophysical Properties for Myogenic, Endothelial, and Osteogenic Cell Guidance

YH Tan, KM Habing, JL Riesterer, ES Stempinksi… - Acta Biomaterialia, 2024 - Elsevier
ABSTRACT A goal of regenerative engineering is the rational design of materials to restore
the structure-function relationships that drive reparative programs in damaged tissues …

[HTML][HTML] Senolytics ameliorate the failure of bone regeneration through the cell senescence-related inflammatory signalling pathway

X Wang, Y Zhou, C Luo, J Zhao, Y Ji, Z Wang… - Biomedicine & …, 2024 - Elsevier
Stress-induced premature senescent (SIPS) cells induced by various stresses deteriorate
cell functions. Dasatinib and quercetin senolytics (DQ) can alleviate several diseases by …

Minimally invasive arthroscopy-assisted arthrodesis for thumb carpometacarpal osteoarthritis

S Komura, A Hirakawa, H Hirose, H Akiyama - Archives of Orthopaedic …, 2024 - Springer
Introduction Arthrodesis is a reliable surgical procedure for treatment of thumb
carpometacarpal (CMC) osteoarthritis that provides hand strength and pain relief. Locking …

[HTML][HTML] Fracture haematoma proteomics: surgical invasiveness characterizes the early fracture healing cascade after multiple trauma

RVM Groven, C Kuik, J Greven, Ü Mert… - Bone & Joint …, 2024 - ncbi.nlm.nih.gov
Aims The aim of this study was to determine the fracture haematoma (fxH) proteome after
multiple trauma using label-free proteomics, comparing two different fracture treatment …

[HTML][HTML] Association of serum thyroid-stimulating hormone and bone mineral density in Chinese adults with normal thyroid function

J Chen, L Hu, N Li, W Deng, X Xu, L Wang… - Nutrition & …, 2024 - ncbi.nlm.nih.gov
Purpose This study aims to investigate the association of serum TSH with BMD in Chinese
adults with normal thyroid function. Methods These participants were divided into tertiles …