NLGN4X TCR transgenic T cells to treat gliomas
Abstract Background Neuroligin 4 X-linked (NLGN4X) harbors a human leukocyte antigen
(HLA)-A* 02-restricted tumor-associated antigen, overexpressed in human gliomas, that was …
(HLA)-A* 02-restricted tumor-associated antigen, overexpressed in human gliomas, that was …
The Impact of Mutational Hotspots on Cancer Survival
M Gonzalez-Cárdenas, V Treviño - Cancers, 2024 - mdpi.com
Simple Summary In cancer, hotspots are those mutations emerging recurrently in tumors.
Hotspots are highly likely to be functional because tumors tend to keep those mutations that …
Hotspots are highly likely to be functional because tumors tend to keep those mutations that …
Transgenic T cell therapy targeting the glioblastoma stem cell antigen PTPRZ1 with a vaccine-induced, patient-derived T cell receptor
L Bunse, YC Chih, AC Dietsch, P Koopmann, X Ma… - 2024 - researchsquare.com
Response to CAR-T cell therapy in glioblastoma (GB) patients is limited, particularly
because of the paucity of cell surface immunotherapeutic targets or low antigen sensitivity …
because of the paucity of cell surface immunotherapeutic targets or low antigen sensitivity …
Engineering minimally immunogenic cargos and delivery modalities for gene therapy
RS Raghavan - 2024 - dspace.mit.edu
Since the discovery of CRISPR-Cas9 systems, gene therapies have revolutionized the field
of molecular biology by introducing functional genes into cells to correct genetic defects or …
of molecular biology by introducing functional genes into cells to correct genetic defects or …