Adaptative survival of Aspergillus fumigatus to echinocandins arises from cell wall remodeling beyond β− 1, 3-glucan synthesis inhibition
Antifungal echinocandins inhibit the biosynthesis of β− 1, 3-glucan, a major and essential
polysaccharide component of the fungal cell wall. However, the efficacy of echinocandins …
polysaccharide component of the fungal cell wall. However, the efficacy of echinocandins …
Molecular architecture of chitin and chitosan-dominated cell walls in zygomycetous fungal pathogens by solid-state NMR
Q Cheng, MC Dickwella Widanage, JR Yarava… - Nature …, 2024 - nature.com
Zygomycetous fungal infections pose an emerging medical threat among individuals with
compromised immunity and metabolic abnormalities. Our pathophysiological understanding …
compromised immunity and metabolic abnormalities. Our pathophysiological understanding …
New Vision of Cell Walls in Aspergillus fumigatus from Solid-State NMR Spectroscopy
The fungal cell wall plays a critical role in regulating cellular integrity and communication,
and serves as a frontline defense against stress. It is also a prime target for the development …
and serves as a frontline defense against stress. It is also a prime target for the development …
[HTML][HTML] Multi-kingdom characterization of living organisms by 13C CPMAS NMR spectroscopy reveals unique traits in bacteria, fungi, algae, and higher plants
Determining the chemical quality of soil organic matter and decomposing organisms is
critical for predicting carbon fluxes in ecosystems. However, the classical C/N and lignin/N …
critical for predicting carbon fluxes in ecosystems. However, the classical C/N and lignin/N …
Comparative Analysis of Polysaccharide and Cell Wall Structure in Aspergillus nidulans and Aspergillus fumigatus by Solid-State NMR
Invasive aspergillosis poses a significant threat to immunocompromised patients, leading to
high mortality rates associated with these infections. Targeting the biosynthesis of cell wall …
high mortality rates associated with these infections. Targeting the biosynthesis of cell wall …