White adipocyte dysfunction and obesity-associated pathologies in humans

CE Hagberg, KL Spalding - Nature Reviews Molecular Cell Biology, 2024 - nature.com
The prevalence of obesity and associated chronic diseases continues to increase
worldwide, negatively impacting on societies and economies. Whereas the association …

[HTML][HTML] Cellular senescence in lung cancer: Molecular mechanisms and therapeutic interventions

SK Jha, G De Rubis, SR Devkota, Y Zhang… - Ageing Research …, 2024 - Elsevier
Lung cancer stands as the primary contributor to cancer-related fatalities worldwide,
affecting both genders. Two primary types exist where non-small cell lung cancer (NSCLC) …

Sustained exposure to high glucose induces differential expression of cellular senescence markers in murine macrophages but impairs immunosurveillance response …

B Diwan, R Yadav, R Goyal, R Sharma - Biogerontology, 2024 - Springer
The influence of chronic diseases on various facets of macrophage cellular senescence is
poorly understood. This study evaluated the impact of chronic hyperglycemia on the …

Lipid droplets, autophagy, and ageing: a cell-specific tale

A Maestri, P Garagnani, M Pedrelli, CE Hagberg… - Ageing Research …, 2024 - Elsevier
Lipid droplets are the essential organelle for storing lipids in a cell. Within the variety of the
human body, different cells store, utilize and release lipids in different ways, depending on …

Combined targeting of senescent cells and senescent macrophages: a new idea for integrated treatment of lung cancer

M Gu, Y Liu, W Zheng, Z Jing, X Li, W Guo… - Seminars in cancer …, 2024 - Elsevier
Lung cancer is one of the most common cancers worldwide and a leading cause of cancer-
related deaths. Macrophages play a key role in the immune response and the tumour …

Longevity and anti-aging effects of curcumin supplementation

M Izadi, N Sadri, A Abdi, MMR Zadeh, D Jalaei… - GeroScience, 2024 - Springer
Aging is a gradual and irreversible process that is accompanied by an overall decline in
cellular function and a significant increase in the risk of age-associated disorders. Generally …

[HTML][HTML] Immunoglobulin G N-glycan markers of accelerated biological aging during chronic HIV infection

LB Giron, Q Liu, OS Adeniji, X Yin, T Kannan… - Nature …, 2024 - nature.com
People living with HIV (PLWH) experience increased vulnerability to premature aging and
inflammation-associated comorbidities, even when HIV replication is suppressed by …

[HTML][HTML] Macrophage senescence in health and diseases

L Wang, W Hong, H Zhu, Q He, B Yang, J Wang… - … Pharmaceutica Sinica B, 2024 - Elsevier
Macrophage senescence, manifested by the special form of durable cell cycle arrest and
chronic low-grade inflammation like senescence-associated secretory phenotype, has long …

Adaptive immunity and atherosclerosis: aging at its crossroads

RPM Snijckers, AC Foks - Frontiers in immunology, 2024 - frontiersin.org
Adaptive immunity plays a profound role in atherosclerosis pathogenesis by regulating
antigen-specific responses, inflammatory signaling and antibody production. However, as …

Phytochemical Screening and Antidiabetic Efficacy of Balanites aegyptiaca Seed Extract and Their Silver Nanoparticles on Muscle and Pancreatic Cell Lines

M Bhardwaj, P Yadav, M Yadav, J Chahal, S Dalal… - ACS …, 2024 - ACS Publications
Balanites aegyptiaca (L.) Delile, a member of the Zygophyllaceae family, is commonly
known as the desert date. This tree is famous for yielding edible fruits and is esteemed for its …