Recent observations suggest a role of the volume of the cerebral ventricle volume, corpus
callosum (CC) segment volume, in particular that of the central-anterior part, and choroid …

Despite the increasing popularity of ambulatory assessment, the reliability and validity of
psychophysiological signals from wearable devices is unproven in daily life settings. We …

Background In mid-later life adults, early-onset and late-onset (ie, onset≥ 50 years)
depression appear to be underpinned by different pathophysiology yet have not been …

Background Late-life depression (LLD) is a prevalent neuropsychiatric disorder in the older
population. While LLD exhibits high mortality rates, depressive symptoms in older adults are …

Background Depression is a major public health concern. A barrier for research has been
the heterogeneous nature of depression, complicated by the categorical diagnosis of …

Abnormalities within the hypothalamic-pituitary-adrenal (HPA) axis and autonomic nervous
system have been implicated in depression. Studies have reported glucocorticoid …

Major depressive disorder (MDD) is a chronic mental illness which affects people's well-
being and is often detected at a later stage of depression with a likelihood of suicidal …

Objective Depression in children and adolescents has gradually attracted social attention.
Heart rate variability (HRV) has been found to be influenced by depression severity, but …

This study examined autonomic nervous system activity (respiratory sinus arrhythmia [RSA])
as a biomarker of psychopathology in an ethnically and socioeconomically diverse sample …

Background Major depressive disorder (MDD) is linked to reduced heart rate variability, an
index of cardiovascular autonomic modulation (CAM). However, treatment effects on CAM …