The information provided from the papers reviewed here about the role of epigenetics in
chronic craniofacial neuropathic pain is critically important because epigenetic …

Current treatments for neurodegenerative diseases and neural injuries face major
challenges, primarily due to the diminished regenerative capacity of neurons in the …

Background Neuropathic pain remains a formidable challenge for modern medicine. The
first‐line pharmacological therapies exhibit limited efficacy and unfavorable side effect …

Trigeminal inflammatory pain is one of the most severe pain-related disorders in humans;
however, the underlying mechanisms remain largely unknown. In this study, we investigated …

Increased expression of angiotensin II AT 1A receptor (encoded by Agtr1a) and Na+-K+-Cl−
cotransporter-1 (NKCC1, encoded by Slc12a2) in the hypothalamic paraventricular nucleus …

Chronic pain and obesity frequently occur together. An ideal therapy would alleviate pain
without weight gain, and most optimally, could promote weight loss. The neuropeptide …

Neuropathic pain (NP), a severe chronic pain condition, remains a substantial clinical
challenge due to its complex pathophysiology and limited effective treatments. An …

The discovery and development of structurally distinct lysine methyltransferase G9a
inhibitors have been the subject of intense research in epigenetics. Structure-based …

Intraoperative remifentanil administration has been linked to increased postoperative pain
sensitivity. Recent studies have identified the involvement of euchromatic histone-lysine N …

Gene expression is influenced by chromatin architecture via controlled access of regulatory
factors to DNA. To better understand regulation of gene expression in the human dorsal root …