Editing of endogenous tubulins reveals varying effects of tubulin posttranslational modifications on axonal growth and regeneration

YM Lu, S Yan, SC Ti, C Zheng - bioRxiv, 2024 - biorxiv.org
Tubulin posttranslational modifications (PTMs) modulate the dynamic properties of
microtubules and their interactions with other proteins. However, the effects of tubulin PTMs …

An in vitro neurogenetics platform for precision disease modeling in the mouse

DE Cortes, M Escudero, AC Korgan, A Mitra… - Science …, 2024 - science.org
The power and scope of disease modeling can be markedly enhanced through the
incorporation of broad genetic diversity. The introduction of pathogenic mutations into a …

Regulation of brain development by the Minibrain/Rala signaling network

M Brown, E Sciascia, K Ning, W Adam, A Veraksa - bioRxiv, 2024 - biorxiv.org
The human dual specificity tyrosine phosphorylation regulated kinase 1A (DYRK1A) is
implicated in the pathology of Down syndrome, microcephaly, and cancer, however the …

Treating disorders associated with dyrk1a dysfunction

P Damon, L Jenna - US Patent App. 18/274,980, 2024 - Google Patents
US20240148835A1 - Treating disorders associated with dyrk1a dysfunction - Google Patents
US20240148835A1 - Treating disorders associated with dyrk1a dysfunction - Google Patents …