Neurotensin and Neurotensin Receptors in Stress-related Disorders: Pathophysiology & Novel Drug Targets
G Kyriatzis, M Khrestchatisky, L Ferhat… - Current …, 2024 - ingentaconnect.com
Neurotensin (NT) is a 13-amino acid neuropeptide widely distributed in the CNS that has
been involved in the pathophysiology of many neural and psychiatric disorders. There are …
been involved in the pathophysiology of many neural and psychiatric disorders. There are …
[HTML][HTML] Hungry for Relief: Potential for Neurotensin to Address Comorbid Obesity and Pain
R Khan, G Laumet, GM Leinninger - Appetite, 2024 - Elsevier
Chronic pain and obesity frequently occur together. An ideal therapy would alleviate pain
without weight gain, and most optimally, could promote weight loss. The neuropeptide …
without weight gain, and most optimally, could promote weight loss. The neuropeptide …
Efferent projections of Nps‐expressing neurons in the parabrachial region
R Zhang, D Huang, S Gasparini… - Journal of Comparative …, 2024 - Wiley Online Library
In the brain, connectivity determines function. Neurons in the parabrachial nucleus (PB)
relay diverse information to widespread brain regions, but the connections and functions of …
relay diverse information to widespread brain regions, but the connections and functions of …
Neurotensin receptor‐1 antagonist SR48692 modulation of high‐fat diet–induced pathogenesis of NAFLD in mice
This study investigates the efficacy of the antagonist of neurotensin receptor‐1 (NTSR1)
SR48692 in modulating the high‐fat diet (HFD)‐induced nonalcoholic fatty liver disease …
SR48692 in modulating the high‐fat diet (HFD)‐induced nonalcoholic fatty liver disease …
Effect of leptin on nitrergic neurons in the lateral hypothalamic area and the supraoptic nucleus of rats
M Hristov, B Landzhov, K Yakimova - Biotechnic & Histochemistry, 2024 - Taylor & Francis
The adipocyte-derived hormone, leptin, plays a key role in the maintenance of energy
homeostasis. Leptin binds to the long form of its receptor, which is predominantly expressed …
homeostasis. Leptin binds to the long form of its receptor, which is predominantly expressed …
[HTML][HTML] β-arrestin-biased Allosteric Modulator of Neurotensin Receptor 1 Reduces Ethanol Drinking and Responses to Ethanol Administration in Rodents
GB Gereau, D Zhou, K Van Voorhies, RE Tyler… - bioRxiv, 2024 - ncbi.nlm.nih.gov
Alcohol use disorders (AUDs) impose an enormous societal and financial burden, and world-
wide, alcohol misuse is the 7 th leading cause of premature death 1. Despite this, there are …
wide, alcohol misuse is the 7 th leading cause of premature death 1. Despite this, there are …