[HTML][HTML] Methodology for awakening the potential secondary metabolic capacity in actinomycetes

S Saito, MA Arai - Beilstein Journal of Organic Chemistry, 2024 - beilstein-journals.org
Secondary metabolites produced by actinomycete strains undoubtedly have great potential
for use in applied research areas such as drug discovery. However, it is becoming difficult to …

Industrial and Pharmaceutical Applications of Microbial Diversity of Hypersaline Ecology from Lonar Soda Crater

P Bawane, S Deshpande, S Yele - Current Pharmaceutical …, 2024 - ingentaconnect.com
The unidentified geochemical and physiochemical characteristics of Soda Lakes across the
globe make it a novel reservoir and bring attention to scientific civic for its conceivable …

[HTML][HTML] Discovery of the Pendulisporaceae: An extremotolerant myxobacterial family with distinct sporulation behavior and prolific specialized metabolism

R Garcia, A Popoff, CD Bader, J Löhr, S Walesch… - Chem, 2024 - cell.com
Myxococcota represents a small bacterial phylum comprising seven families, which have
been shown to be exceptionally rich producers of pharmaceutically interesting natural …

Biosynthesis of novel desferrioxamine derivatives requires unprecedented crosstalk between separate NRPS-independent siderophore pathways

L Su, Y Souaibou, L Hôtel, C Paris… - Applied and …, 2024 - Am Soc Microbiol
Iron is essential to many biological processes but its poor solubility in aerobic environments
restricts its bioavailability. To overcome this limitation, bacteria have evolved a variety of …

Functional antagonism and insights into the biosynthetic potential of human gut-derived microbes

A Hussain, U Patwekar, DS Mongad… - International Journal of …, 2024 - Elsevier
The specialised small molecules encoded by commensal microbes mediate distinct
functional interactions. However, there is a landscape of antagonistic interactions mediated …

[HTML][HTML] A Genomics-Based Discovery of Secondary Metabolite Biosynthetic Gene Clusters in the Potential Novel Strain Streptomyces sp. 21So2-11 Isolated from …

Y Du, W Han, P Hao, Y Hu, T Hu, Y Zeng - Microorganisms, 2024 - mdpi.com
Streptomyces species are attractive sources of secondary metabolites that serve as major
sources of antibiotics and other drugs. In this study, genome mining was used to determine …

Genomes and secondary metabolomes of Streptomyces spp. isolated from Leontopodium nivale ssp. alpinum

F Malfent, M Zehl, RH Kirkegaard… - Frontiers in …, 2024 - frontiersin.org
Bacterial endophytes dwelling in medicinal plants represent an as yet underexplored source
of bioactive natural products with the potential to be developed into drugs against various …