Introduction Colorectal cancer (CRC) is one of the most prevalent and lethal cancers
worldwide. The treatment of metastatic colorectal cancer (mCRC) is difficult, and mCRC has …

The last two decades have witnessed major breakthroughs in the development of targeted
therapy for patients with metastatic colorectal cancer (mCRC), an achievement which stems …

Cetuximab therapy is the major treatment for colorectal cancer (CRC), but drug resistance
limits its effectiveness. Here, we perform longitudinal and deep proteomic profiling of 641 …

Colorectal cancer (CRC) is the fourth most frequently diagnosed cancer and the second
leading cause of cancer death in the United States. Management of disseminated metastatic …

Background The prognosis of malignant primary high-grade brain tumors, predominantly
glioblastomas, is poor despite intensive multimodality treatment options. In more than 50 …

Background Anti-epidermal growth factor receptor (EGFR) antibodies often cause skin
toxicities. Preemptive skin treatments using systemic antibiotics with or without topical …

Colorectal cancer is the third most prevalent cancer worldwide, and its treatment has been a
demanding clinical problem. Beyond traditional surgical therapy and chemotherapy, newly …

Exosomes are secreted vesicles made intracellularly in the endosomal system. We have
previously shown that exosomes are not only made in late endosomes, but also in recycling …

The application of network pharmacology (NP) has advanced our understanding of the
complex molecular mechanisms underlying diseases, including neck, head, and oral …

Background: Different RAS/BRAF allele mutations imply distinct biological properties in
various solid tumors. Recently, several studies have focused on the predictive and …