RNA modifications in cellular metabolism: implications for metabolism-targeted therapy and immunotherapy

WW Liu, SQ Zheng, T Li, YF Fei, C Wang… - … and Targeted Therapy, 2024 - nature.com
Cellular metabolism is an intricate network satisfying bioenergetic and biosynthesis
requirements of cells. Relevant studies have been constantly making inroads in our …

m6A-Atlas v2.0: updated resources for unraveling the N6-methyladenosine (m6A) epitranscriptome among multiple species

Z Liang, H Ye, J Ma, Z Wei, Y Wang… - Nucleic Acids …, 2024 - academic.oup.com
Abstract N 6-Methyladenosine (m6A) is one of the most abundant internal chemical
modifications on eukaryote mRNA and is involved in numerous essential molecular …

RNA methylation‐related inhibitors: biological basis and therapeutic potential for cancer therapy

H Chen, H Liu, C Zhang, N Xiao, Y Li… - Clinical and …, 2024 - Wiley Online Library
RNA methylation is widespread in nature. Abnormal expression of proteins associated with
RNA methylation is strongly associated with a number of human diseases including cancer …

RNA m6A reader YTHDF2 facilitates precursor miR-126 maturation to promote acute myeloid leukemia progression

Z Zhang, K Zhou, L Han, A Small, J Xue, H Huang… - Genes & …, 2024 - Elsevier
As the most common internal modification of mRNA, N 6-methyladenosine (m 6 A) and its
regulators modulate gene expression and play critical roles in various biological and …

[HTML][HTML] Targeting PRMT9-mediated arginine methylation suppresses cancer stem cell maintenance and elicits cGAS-mediated anticancer immunity

H Dong, X He, L Zhang, W Chen, YC Lin, SB Liu… - Nature Cancer, 2024 - nature.com
Current anticancer therapies cannot eliminate all cancer cells, which hijack normal arginine
methylation as a means to promote their maintenance via unknown mechanisms. Here we …

A novel AML1-ETO/FTO positive feedback loop promotes leukemogenesis and Ara-C resistance via stabilizing IGFBP2 in t (8; 21) acute myeloid leukemia

W Zhou, S Li, H Wang, J Zhou, S Li, G Chen… - … Hematology & Oncology, 2024 - Springer
Abstract Background t (8; 21)(q22; q22) is one of the most frequent chromosomal
abnormalities in acute myeloid leukemia (AML), leading to the generation of the fusion …

Targeting FTO induces colorectal cancer ferroptotic cell death by decreasing SLC7A11/GPX4 expression

Y Qiao, M Su, H Zhao, H Liu, C Wang, X Dai… - Journal of Experimental …, 2024 - Springer
Ferroptosis is a newly identified iron-dependent form of death that is becoming increasingly
recognized as a promising avenue for cancer therapy. N6-methyladenosine (m6A) is the …

[HTML][HTML] Clinical Perspectives in Epitranscriptomics

E Santos-Pujol, C Quero-Dotor, M Esteller - Current Opinion in Genetics & …, 2024 - Elsevier
Highlights•Epitranscriptomics refers to all chemical marks on RNA regulating gene
expression.•The epitranscriptome is altered in several prevalent diseases.•Disease-specific …

Inhibition of METTL3 in macrophages provides protection against intestinal inflammation

H Yin, Z Ju, X Zhang, W Zuo, Y Yang… - Cellular & Molecular …, 2024 - nature.com
Inflammatory bowel disease (IBD) is prevalent, and no satisfactory therapeutic options are
available because the mechanisms underlying its development are poorly understood. In …

Small molecule inhibitors targeting m6A regulators

G Feng, Y Wu, Y Hu, W Shuai, X Yang, Y Li… - Journal of Hematology & …, 2024 - Springer
As the most common form of epigenetic regulation by RNA, N6 methyladenosine (m6A)
modification is closely involved in physiological processes, such as growth and …