[PDF][PDF] Progress in the study of intestinal microbiota involved in morphine tolerance

K Bi, Y Lei, D Kong, Y Li, X Fan, X Luo, J Yang, G Wang… - Heliyon, 2024 - cell.com
Morphine is a widely used opioid for treatment of pain. The attendant problems including
morphine tolerance and morphine dependence pose a major public health challenge. In …

Microglial Nrf2/HO-1 signaling gates remifentanil-induced hyperalgesia via suppressing TRPV4-mediated M1 polarization

X Liu, H Cai, L Peng, H Ma, Y Yan, W Li… - Free Radical Biology and …, 2024 - Elsevier
Remifentanil-induced hyperalgesia (RIH) represents a significant clinical challenge due to
the widespread use of opioids in pain management. However, the molecular and cellular …

Remote automated delivery of mechanical stimuli coupled to brain recordings in behaving mice

J Burdge, A Jhumka, S Ogundare, N Baer, S Fulton… - bioRxiv, 2024 - biorxiv.org
The canonical framework for testing pain and mechanical sensitivity in rodents is manual
delivery of stimuli to the paw. However, this approach can produce variability in results …