Abstract N 6-methyladenosine (m 6 A) is the most abundant posttranscriptional chemical
modification in mRNA, involved in regulating various physiological and pathological …

Sepsis is a systemic response to infection with life-threatening consequences. Our
understanding of the molecular and cellular impact of sepsis across organs remains …

RNA editing, a common and potentially highly functional form of RNA modification,
encompasses two different RNA modifications, namely adenosine to inosine (A-to-I) and …

COVID-19 patients commonly present with signs of central nervous system and/or peripheral
nervous system dysfunction. Here, we show that midbrain dopamine (DA) neurons derived …

Single-cell RNA sequencing (scRNA-seq) has emerged as a powerful technique for
investigating biological heterogeneity at the single-cell level in human systems and model …

Understanding somatic cell totipotency remains a challenge facing scientific inquiry today.
Plants display remarkable cell totipotency expression, illustrated by single-cell differentiation …

Unique molecular identifiers are random oligonucleotide sequences that remove PCR
amplification biases. However, the impact that PCR associated sequencing errors have on …

Colorectal cancer (CRC) is the third most prevalent and second most lethal cancer globally,
with gene mutations and tumor metastasis contributing to its poor prognosis. Single-cell …

Mutation analysis is typically performed at the DNA level since most technical approaches
are developed for DNA analysis. However, some applications, like transcriptional …

Orthopedic conditions have emerged as global health concerns, impacting approximately
1.7 billion individuals worldwide. However, the limited understanding of the underlying …