Endometriosis and polycystic ovary syndrome (PCOS) are two common female reproductive
disorders with a significant impact on the health and quality of life of women affected. A …

Kisspeptin (KP) and neurokinin B (NKB) are neuropeptides that govern the reproductive
endocrine axis through regulating hypothalamic gonadotropin-releasing hormone (GnRH) …

There are 3 physiological waves of central hypothalamic-pituitary-gonadal (HPG) axis
activity over the lifetime. The first occurs during fetal life, the second—termed “mini-puberty” …

Among the premenopausal women, Polycystic Ovary Syndrome (PCOS) is the most
prevalent endocrinopathy affecting the reproductive system and metabolic rhythms leading …

The typical timing of male puberty begins between 9 and 14 years old, at an average age of
11.6 Æ 0.9 years. 1 Luteinizing hormone (LH), measured via an ultrasensitive assay, acts as …

Objectives The etiology of central precocious puberty (CPP) has expanded with
identification of new genetic causes, including the monogenic deficiency of MKRN3. We …

Pubertal timing, including age at menarche (AAM), is a heritable trait linked to lifetime health
outcomes. Here, we investigate genetic mechanisms underlying AAM by combining GWAS …

Infertility is becoming increasingly common, affecting one in six people globally. Half of
these cases can be attributed to male factors, many driven by abnormalities in the process of …

Understanding the pathophysiology of idiopathic central precocious puberty (ICPP) is
essential, in view of its consequences on reproductive health and metabolic disorders in …

Methods Eighteen familial CPP cases were investigated by Sanger sequencing for five CPP-
related genes; DLK1, KISS1, KISS1R, MKRN3, and PROKR2. Segregation analysis was …