[HTML][HTML] Harnessing CRISPR technology for viral therapeutics and vaccines: from preclinical studies to clinical applications
F Zahedipour, F Zahedipour, P Zamani, MR Jaafari… - Virus Research, 2024 - Elsevier
The CRISPR/Cas system, identified as a type of bacterial adaptive immune system, have
attracted significant attention due to its remarkable ability to precisely detect and eliminate …
attracted significant attention due to its remarkable ability to precisely detect and eliminate …
Delivering CRISPR to the HIV-1 reservoirs
TE Gurrola, SN Effah, IK Sariyer, W Dampier… - Frontiers in …, 2024 - frontiersin.org
Human immunodeficiency virus type 1 (HIV-1) infection is well known as one of the most
complex and difficult viral infections to cure. The difficulty in developing curative strategies …
complex and difficult viral infections to cure. The difficulty in developing curative strategies …
Preclinical toxicity analyses of lentiviral vectors expressing the HIV-1 LTR-specific designer-recombinase Brec1
N Beschorner, P Künzle, M Voges, I Hauber… - Plos one, 2024 - journals.plos.org
Drug-based antiretroviral therapies (ART) efficiently suppress HIV replication in humans, but
the virus persists as integrated proviral reservoirs in small numbers of cells. Importantly, ART …
the virus persists as integrated proviral reservoirs in small numbers of cells. Importantly, ART …
[HTML][HTML] A temperature-sensitive and interferon-silent Sendai virus vector for CRISPR-Cas9 delivery and gene editing in primary human cells
CS Stevens, J Carmichael, R Watkinson, S Kowdle… - bioRxiv, 2024 - ncbi.nlm.nih.gov
The transformative potential of gene editing technologies hinges on the development of safe
and effective delivery methods. In this study, we developed a temperature-sensitive and …
and effective delivery methods. In this study, we developed a temperature-sensitive and …
CRISPR/Cas-based diagnosis and treatment of infectious diseases
X Wang, Y Li, X Huang - Molecular Medical Microbiology, 2024 - Elsevier
The CRISPR/Cas systems, discovered in many bacteria as an adaptive immune mechanism
against foreign nucleic acids, have been repurposed as tools for antiviral therapeutics and …
against foreign nucleic acids, have been repurposed as tools for antiviral therapeutics and …
[HTML][HTML] High-resolution Inference of Multiplexed Anti-HIV Gene Editing using Single-Cell Targeted DNA Sequencing
MS Bouzidi, ZY Dossani, C Di Benedetto, KA Raymond… - bioRxiv, 2024 - ncbi.nlm.nih.gov
Gene therapy-based HIV cure strategies typically aim to excise the HIV provirus directly, or
target host dependency factors (HDFs) that support viral persistence. Cure approaches will …
target host dependency factors (HDFs) that support viral persistence. Cure approaches will …
Therapeutic applications of CRISPR-Cas system in infectious diseases
H Zhang - … Conference on Biological Engineering and Medical …, 2024 - spiedigitallibrary.org
A serious threat to world health is posed by infectious illnesses. Increased resistance to
antimicrobial drugs by microorganisms and others, chronic infections that cannot be cured …
antimicrobial drugs by microorganisms and others, chronic infections that cannot be cured …