Heterogeneity in functional connectivity: dimensional predictors of individual variability during rest and task fMRI in psychosis

MT Secara, LD Oliver, J Gallucci, EW Dickie… - Progress in Neuro …, 2024 - Elsevier
Background Individuals with schizophrenia spectrum disorders (SSD) often demonstrate
cognitive impairments, associated with poor functional outcomes. While neurobiological …

[HTML][HTML] De Novo Variants Found in Three Distinct Schizophrenia Populations Hit a Common Core Gene Network Related to Microtubule and Actin Cytoskeleton Gene …

Y Loe-Mie, C Plançon, C Dubertret, T Yoshikawa… - Life, 2024 - mdpi.com
Schizophrenia (SZ) is a heterogeneous and debilitating psychiatric disorder with a strong
genetic component. To elucidate functional networks perturbed in schizophrenia, we …

Transcriptomic and epigenomic consequences of heterozygous loss of function mutations in AKAP11, the first large-effect shared risk gene for bipolar disorder and …

N Farhangdoost, C Liao, Y Liu, M Alda, PA Dion… - bioRxiv, 2024 - biorxiv.org
The gene A-kinase anchoring protein 11 (AKAP11) recently emerged as a shared risk factor
between bipolar disorder and schizophrenia, driven by large-effect loss-of-function (LoF) …