Treating primary aldosteronism-induced hypertension: novel approaches and future outlooks

N Mullen, J Curneen, PT Donlon, P Prakash… - Endocrine …, 2024 - academic.oup.com
Primary aldosteronism (PA) is the most common cause of secondary hypertension and is
associated with increased morbidity and mortality when compared with blood pressure …

Mild autonomous cortisol secretion: pathophysiology, comorbidities and management approaches

A Prete, I Bancos - Nature Reviews Endocrinology, 2024 - nature.com
The majority of incidentally discovered adrenal tumours are benign adrenocortical
adenomas and the prevalence of adrenocortical adenomas is around 1–7% on cross …

[HTML][HTML] Urine steroid metabolomics as a diagnostic tool in primary aldosteronism

A Prete, K Lang, D Pavlov, Y Rhayem, AJ Sitch… - The Journal of Steroid …, 2024 - Elsevier
Abstract Primary aldosteronism (PA) causes 5–10% of hypertension cases, but only a
minority of patients are currently diagnosed and treated because of a complex, stepwise …

Effect of mild cortisol cosecretion on body composition and metabolic parameters in patients with primary hyperaldosteronism

N Mansour, D Bruedgam, U Dischinger… - Clinical …, 2024 - Wiley Online Library
Objective To investigate the effects of simultaneous cortisol cosecretion (CCS) on body
composition in computed tomography (CT)‐imaging and metabolic parameters in patients …

Comparison of adrenalectomy with conservative treatment on mild autonomous cortisol secretion: a systematic review and meta-analysis

MM Khadembashiri, S Mohseni, H Harandi… - Frontiers in …, 2024 - frontiersin.org
Objective This systematic review and meta-analysis was conducted to compare the benefits
of adrenalectomy and conservative treatment for comorbidities associated with mild …

Moderate salt restriction in primary aldosteronism improves bone metabolism through attenuation of urinary calcium and phosphate losses

H Schneider, D Brüdgam, HF Nowotny… - European Journal of …, 2024 - academic.oup.com
Accumulating evidence links osteoporosis and dietary salt consumption. Primary
aldosteronism (PA) is a model disease with increased dietary salt intake and constitutes an …

Iatrogenic adrenal insufficiency in adults

J Martin-Grace, M Tomkins, MW O'Reilly… - Nature Reviews …, 2024 - nature.com
Iatrogenic adrenal insufficiency (IAI) is the most common form of adrenal insufficiency in
adult patients, although its overall exact prevalence remains unclear. IAI is associated with …

Single-Nucleus Analysis Reveals Tumor Heterogeneity of Aldosterone-Producing Adenoma

M Murakami, K Hara, K Ikeda, M Horino, R Okazaki… - …, 2024 - Am Heart Assoc
BACKGROUND: Recent advances in omics techniques have allowed detailed genetic
characterization of aldosterone-producing adenoma (APA). The pathogenesis of APA is …

Clinical and imaging presentations are associated with function in incidental adrenocortical adenomas: a retrospective cohort study

O Hamidi, M Shah, CD Zhang, N Lazik… - European Journal of …, 2024 - academic.oup.com
Objective The aim of this study is to assess whether clinical and imaging characteristics are
associated with the hormonal subtype, growth, and adrenalectomy for incidental adrenal …

Association of adrenal steroids with metabolomic profiles in patients with primary and endocrine hypertension

R Knuchel, Z Erlic, S Gruber, L Amar… - Frontiers in …, 2024 - frontiersin.org
Introduction Endocrine hypertension (EHT) due to pheochromocytoma/paraganglioma
(PPGL), Cushing's syndrome (CS), or primary aldosteronism (PA) is linked to a variety of …