Dorsal root ganglia (DRG) somatosensory neurons detect mechanical, thermal, and
chemical stimuli acting on the body. Achieving a holistic view of how different DRG neuron …

Thermosensors expressed in peripheral somatosensory neurons sense a wide range of
environmental temperatures. While thermosensors detecting cool, warm and hot …

The mammalian brain controls heat generation and heat loss mechanisms that regulate
body temperature and energy metabolism. Thermoeffectors include brown adipose tissue …

Thermoregulation is critical for survival across species. In animals, the nervous system
detects external and internal temperatures, integrates this information with internal states …

Krause corpuscles, which were discovered in the 1850s, are specialized sensory structures
found within the genitalia and other mucocutaneous tissues,,–. The physiological properties …

Neurotrophic keratopathy (NK) is a challenging disease with the reduced innervation to the
cornea. To establish a genetic and stable mouse model of NK, we utilized the TRPV1-DTR …

Cooling sensations arise inside the mouth during ingestive and homeostasis behaviors. Oral
presence of cooling temperature engages the cold and menthol receptor TRPM8 (transient …

Cold injury or frostbite is a common medical condition that causes serious clinical
complications including sensory abnormalities and chronic pain ultimately affecting overall …

Thermoregulation is synchronized across the circadian cycle to uphold thermal
homeostasis. To test if time-of-day matters for the response to environmental cold exposure …

Summary N-and P/Q-type voltage-gated Ca 2+ channels are critical for synaptic
transmission. While their expression is increased in the dorsal root ganglion (DRG) neuron …