[HTML][HTML] A mouse DRG genetic toolkit reveals morphological and physiological diversity of somatosensory neuron subtypes
Dorsal root ganglia (DRG) somatosensory neurons detect mechanical, thermal, and
chemical stimuli acting on the body. Achieving a holistic view of how different DRG neuron …
chemical stimuli acting on the body. Achieving a holistic view of how different DRG neuron …
The kainate receptor GluK2 mediates cold sensing in mice
Thermosensors expressed in peripheral somatosensory neurons sense a wide range of
environmental temperatures. While thermosensors detecting cool, warm and hot …
environmental temperatures. While thermosensors detecting cool, warm and hot …
Neural circuits of long-term thermoregulatory adaptations to cold temperatures and metabolic demands
The mammalian brain controls heat generation and heat loss mechanisms that regulate
body temperature and energy metabolism. Thermoeffectors include brown adipose tissue …
body temperature and energy metabolism. Thermoeffectors include brown adipose tissue …
Vertebrate behavioral thermoregulation: knowledge and future directions
B Cutler, M Haesemeyer - Neurophotonics, 2024 - spiedigitallibrary.org
Thermoregulation is critical for survival across species. In animals, the nervous system
detects external and internal temperatures, integrates this information with internal states …
detects external and internal temperatures, integrates this information with internal states …
Krause corpuscles are genital vibrotactile sensors for sexual behaviours
Krause corpuscles, which were discovered in the 1850s, are specialized sensory structures
found within the genitalia and other mucocutaneous tissues,,–. The physiological properties …
found within the genitalia and other mucocutaneous tissues,,–. The physiological properties …
Establishment of mouse model of neurotrophic keratopathy through TRPV1 neuronal ablation
L Zhao, R Chen, J Qu, L Yang, Y Li, L Ma… - Experimental Eye …, 2024 - Elsevier
Neurotrophic keratopathy (NK) is a challenging disease with the reduced innervation to the
cornea. To establish a genetic and stable mouse model of NK, we utilized the TRPV1-DTR …
cornea. To establish a genetic and stable mouse model of NK, we utilized the TRPV1-DTR …
Separation of oral cooling and warming requires TRPM8
Cooling sensations arise inside the mouth during ingestive and homeostasis behaviors. Oral
presence of cooling temperature engages the cold and menthol receptor TRPM8 (transient …
presence of cooling temperature engages the cold and menthol receptor TRPM8 (transient …
Dermorphin [D-Arg2, Lys4](1-4) Amide Alleviates Frostbite-Induced Pain by Regulating TRP Channel-Mediated Microglial Activation and Neuroinflammation
Cold injury or frostbite is a common medical condition that causes serious clinical
complications including sensory abnormalities and chronic pain ultimately affecting overall …
complications including sensory abnormalities and chronic pain ultimately affecting overall …
Timing of acute cold exposure determines UCP1 and FGF21 expression-possible interactions between the thermal environment, thermoregulatory responses, and …
Thermoregulation is synchronized across the circadian cycle to uphold thermal
homeostasis. To test if time-of-day matters for the response to environmental cold exposure …
homeostasis. To test if time-of-day matters for the response to environmental cold exposure …
Functional remodeling of presynaptic voltage-gated calcium channels in superficial layers of the dorsal horn during neuropathic pain
Summary N-and P/Q-type voltage-gated Ca 2+ channels are critical for synaptic
transmission. While their expression is increased in the dorsal root ganglion (DRG) neuron …
transmission. While their expression is increased in the dorsal root ganglion (DRG) neuron …