Currently, immune checkpoint blockade (ICB) therapies that target the programmed cell
death ligand-1 (PD-L1) have been used as revolutionary cancer treatments in the clinic …

Epithelioid sarcoma (EpS) is an ultra-rare malignant soft-tissue cancer mostly affecting
adolescents and young adults. EpS often exhibits an unfavorable clinical course with fatal …

Attenuated measles virus (MV) exerts its oncolytic activity in malignant pleural mesothelioma
(MPM) cells that lack type-I interferon (IFN-I) production or responsiveness. However, other …

Oncolytic viruses are multifaceted tumor killers, which can function as tumor vaccines to
boost systemic antitumor immunity. In previous study, we rationally designed a synthetic …

Cancer immunotherapy has emerged as a promising approach for the treatment of various
cancers. However, the immunosuppressive tumor microenvironment (TME) limits the efficacy …

SMARCA4-deficient undifferentiated thoracic tumor is extremely invasive. This tumor with
poor prognosis is easily confused with SMARCA4-deficent non-small cell lung cancer or …

Background Clinical data indicate that a substantial portion of cancer patients, though
eligible for immune checkpoint inhibitor (ICI) therapy, cannot fully benefit from ICI …

Colorectal cancer (CRC) is known to be resistant to immunotherapy. In our phase-I clinical
trial, one patient achieved a 313-day prolonged response during the combined treatment of …

Adenoviruses are non-enveloped DNA viruses that cause a wide range of symptoms, from
mild infections to life-threatening diseases in a broad range of hosts. Due to the unique …

Cancer, ranked as the second leading cause of mortality worldwide, leads to the death of
approximately seven million people annually, establishing itself as one of the most …