Aging, as a complex process involving multiple cellular and molecular pathways, is known to
be exacerbated by various stresses. Because responses to these stresses, such as oxidative …

A growing class of small RNAs, known as tRNA-derived RNAs (tdRs), tRNA-derived small
RNAs or tRNA-derived fragments, have long been considered mere intermediates of tRNA …

Current research on human aging has largely been guided by the milestone paper
“hallmarks of aging,” which were first proposed in the seminal 2013 paper by Lopez‐Otin et …

Accumulation of senescent cells in organs and tissues is a hallmark of aging and known to
contribute to age-related diseases. Although aging-associated immune dysfunction, or …

Oncogene-induced replication stress generates endogenous DNA damage that activates
cGAS–STING-mediated signalling and tumour suppression,–. However, the precise …

Cellular senescence was initially described in the early 1960s by Hayflick and Moorehead.
They noted sustained cell-cycle arrest after repeated subculturing of human primary cells …

Bacterial genotoxins damage host cells by targeting their chromosomal DNA. In the present
study, we demonstrate that a genotoxin of Salmonella Typhi, typhoid toxin, triggers the …

DNA damage and neurodegenerative disorders are intimately linked but the underlying
mechanism remains elusive. Here, we show that persistent DNA lesions in tissue-resident …

As the leading cause of disability worldwide, low back pain (LBP) is recognized as a pivotal
socioeconomic challenge to the aging population and is largely attributed to intervertebral …

Cadmium (Cd) is a widely distributed typical environmental pollutant and one of the most
toxic heavy metals. It is well-known that environmental Cd causes testicular damage by …