Linking brain activity across scales with simultaneous opto-and electrophysiology
CM Lewis, A Hoffmann, F Helmchen - Neurophotonics, 2024 - spiedigitallibrary.org
The brain enables adaptive behavior via the dynamic coordination of diverse neuronal
signals across spatial and temporal scales: from fast action potential patterns in microcircuits …
signals across spatial and temporal scales: from fast action potential patterns in microcircuits …
[HTML][HTML] Activity-dependent compartmentalization of dendritic mitochondria morphology through local regulation of fusion-fission balance in neurons in vivo
Neuronal mitochondria play important roles beyond ATP generation, including Ca2+ uptake,
and therefore have instructive roles in synaptic function and neuronal response properties …
and therefore have instructive roles in synaptic function and neuronal response properties …
Synaptic wiring motifs in posterior parietal cortex support decision-making
The posterior parietal cortex exhibits choice-selective activity during perceptual decision-
making tasks,,,,,,,,–. However, it is not known how this selective activity arises from the …
making tasks,,,,,,,,–. However, it is not known how this selective activity arises from the …
Directed and acyclic synaptic connectivity in the human layer 2-3 cortical microcircuit
Y Peng, A Bjelde, PV Aceituno, FX Mittermaier… - Science, 2024 - science.org
The computational capabilities of neuronal networks are fundamentally constrained by their
specific connectivity. Previous studies of cortical connectivity have mostly been carried out in …
specific connectivity. Previous studies of cortical connectivity have mostly been carried out in …
[HTML][HTML] A deep-learning strategy to identify cell types across species from high-density extracellular recordings
M Beau, DJ Herzfeld, F Naveros, ME Hemelt… - bioRxiv, 2024 - ncbi.nlm.nih.gov
High-density probes allow electrophysiological recordings from many neurons
simultaneously across entire brain circuits but don't reveal cell type. Here, we develop a …
simultaneously across entire brain circuits but don't reveal cell type. Here, we develop a …
[HTML][HTML] Synaptic configuration and reconfiguration in the neocortex are spatiotemporally selective
J Sohn - Anatomical Science International, 2024 - Springer
Brain computation relies on the neural networks. Neurons extend the neurites such as
dendrites and axons, and the contacts of these neurites that form chemical synapses are the …
dendrites and axons, and the contacts of these neurites that form chemical synapses are the …
Astrocyte ensheathment of calyx‐forming axons of the auditory brainstem precedes accelerated expression of myelin genes and myelination by oligodendrocytes
DT Heller, DR Kolson, AN Brandebura… - Journal of …, 2024 - Wiley Online Library
Early postnatal brain development involves complex interactions among maturing neurons
and glial cells that drive tissue organization. We previously analyzed gene expression in …
and glial cells that drive tissue organization. We previously analyzed gene expression in …
[HTML][HTML] Petascale pipeline for precise alignment of images from serial section electron microscopy
The reconstruction of neural circuits from serial section electron microscopy (ssEM) images
is being accelerated by automatic image segmentation methods. Segmentation accuracy is …
is being accelerated by automatic image segmentation methods. Segmentation accuracy is …
[HTML][HTML] Most axonal mitochondria in cortical pyramidal neurons lack mitochondrial DNA and consume ATP
In neurons of the mammalian central nervous system (CNS), axonal mitochondria are
thought to be indispensable for supplying ATP during energy-consuming processes such as …
thought to be indispensable for supplying ATP during energy-consuming processes such as …
[HTML][HTML] Dendrite architecture determines mitochondrial distribution patterns in vivo
EJ Donovan, A Agrawal, N Liberman, JI Kalai, AJ Adler… - Cell Reports, 2024 - cell.com
Neuronal morphology influences synaptic connectivity and neuronal signal processing.
However, it remains unclear how neuronal shape affects steady-state distributions of …
However, it remains unclear how neuronal shape affects steady-state distributions of …