Linking brain activity across scales with simultaneous opto-and electrophysiology

CM Lewis, A Hoffmann, F Helmchen - Neurophotonics, 2024 - spiedigitallibrary.org
The brain enables adaptive behavior via the dynamic coordination of diverse neuronal
signals across spatial and temporal scales: from fast action potential patterns in microcircuits …

[HTML][HTML] Activity-dependent compartmentalization of dendritic mitochondria morphology through local regulation of fusion-fission balance in neurons in vivo

DM Virga, S Hamilton, B Osei, A Morgan… - Nature …, 2024 - nature.com
Neuronal mitochondria play important roles beyond ATP generation, including Ca2+ uptake,
and therefore have instructive roles in synaptic function and neuronal response properties …

Synaptic wiring motifs in posterior parietal cortex support decision-making

AT Kuan, G Bondanelli, LN Driscoll, J Han, M Kim… - Nature, 2024 - nature.com
The posterior parietal cortex exhibits choice-selective activity during perceptual decision-
making tasks,,,,,,,,–. However, it is not known how this selective activity arises from the …

Directed and acyclic synaptic connectivity in the human layer 2-3 cortical microcircuit

Y Peng, A Bjelde, PV Aceituno, FX Mittermaier… - Science, 2024 - science.org
The computational capabilities of neuronal networks are fundamentally constrained by their
specific connectivity. Previous studies of cortical connectivity have mostly been carried out in …

[HTML][HTML] A deep-learning strategy to identify cell types across species from high-density extracellular recordings

M Beau, DJ Herzfeld, F Naveros, ME Hemelt… - bioRxiv, 2024 - ncbi.nlm.nih.gov
High-density probes allow electrophysiological recordings from many neurons
simultaneously across entire brain circuits but don't reveal cell type. Here, we develop a …

[HTML][HTML] Synaptic configuration and reconfiguration in the neocortex are spatiotemporally selective

J Sohn - Anatomical Science International, 2024 - Springer
Brain computation relies on the neural networks. Neurons extend the neurites such as
dendrites and axons, and the contacts of these neurites that form chemical synapses are the …

Astrocyte ensheathment of calyx‐forming axons of the auditory brainstem precedes accelerated expression of myelin genes and myelination by oligodendrocytes

DT Heller, DR Kolson, AN Brandebura… - Journal of …, 2024 - Wiley Online Library
Early postnatal brain development involves complex interactions among maturing neurons
and glial cells that drive tissue organization. We previously analyzed gene expression in …

[HTML][HTML] Petascale pipeline for precise alignment of images from serial section electron microscopy

S Popovych, T Macrina, N Kemnitz, M Castro… - Nature …, 2024 - nature.com
The reconstruction of neural circuits from serial section electron microscopy (ssEM) images
is being accelerated by automatic image segmentation methods. Segmentation accuracy is …

[HTML][HTML] Most axonal mitochondria in cortical pyramidal neurons lack mitochondrial DNA and consume ATP

Y Hirabayashi, TL Lewis Jr, Y Du, DM Virga… - bioRxiv, 2024 - ncbi.nlm.nih.gov
In neurons of the mammalian central nervous system (CNS), axonal mitochondria are
thought to be indispensable for supplying ATP during energy-consuming processes such as …

[HTML][HTML] Dendrite architecture determines mitochondrial distribution patterns in vivo

EJ Donovan, A Agrawal, N Liberman, JI Kalai, AJ Adler… - Cell Reports, 2024 - cell.com
Neuronal morphology influences synaptic connectivity and neuronal signal processing.
However, it remains unclear how neuronal shape affects steady-state distributions of …