Germline variation and somatic mutation are intricately connected and together shape
human traits and disease risks. Germline variants are present from conception, but they vary …

Clonal haematopoiesis of indeterminate potential (CHIP) is a preclinical condition wherein a
sizeable proportion of an individual's circulating blood cells are derived from a single …

Clonal hematopoiesis of indeterminate potential (CHIP) is a common age-related
phenomenon in which hematopoietic stem cells acquire mutations in a select set of genes …

Clonal hematopoiesis (CH) can be caused by either single gene mutations (eg point
mutations in JAK2 causing CHIP) or mosaic chromosomal alterations (eg, loss of …

Genome-wide association studies (GWAS) have become well-powered to detect loci
associated with telomere length. However, no prior work has validated genes nominated by …

Clonal hematopoiesis (CH) identified by somatic gene variants with variant allele fraction
(VAF)≥ 2% is associated with an increased risk of hematologic malignancy. However, CH …

Loss of stem cell regenerative potential underlies aging of all tissues. Somatic mosaicism,
the emergence of cellular patchworks within tissues, increases with age and has been …

Clonal hematopoiesis (CH) is characterized by the acquisition of a somatic mutation in a
hematopoietic stem cell that results in a clonal expansion. These driver mutations can be …

Clonal hematopoiesis of indeterminate potential (CHIP), whereby somatic mutations in
hematopoietic stem cells confer a selective advantage and drive clonal expansion, not only …

The study of somatic mutations and the associated clonal mosaicism across the human body
has transformed our understanding of aging and its links to cancer. In proliferative human …